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Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal
transition via the PI3K-AKT pathway in breast cancer
#MMPMID26191181
Xu S
; Sui S
; Zhang J
; Bai N
; Shi Q
; Zhang G
; Gao S
; You Z
; Zhan C
; Liu F
; Pang D
Int J Clin Exp Pathol
2015[]; 8
(5
): 4881-91
PMID26191181
show ga
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) regulates
cell motility via the transcriptional or post-transcriptional control of
motility-related genes. Whether MALAT1 plays a critical role in cancer
progression in breast cancer remains unclear. In this study, we found that MALAT1
was downregulated in breast tumor cell lines and cancer tissue, and showed that
knockdown of MALAT1 in breast cancer cell lines induced an
epithelial-to-mesenchymal transition (EMT) program via phosphatidylinositide-3
kinase-AKT pathways. Furthermore, lower expression of MALAT1 in breast cancer
patients was associated with shorter relapse-free survival. Thus, our results
indicate for the first time that MALAT1 is a novel regulator of EMT in breast
cancer and may be a potential therapeutic target for breast cancer metastasis.
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