Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12967-015-0590-1 http://scihub22266oqcxt.onion/10.1186/s12967-015-0590-1 C4502949!4502949!26174551     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Transl+Med 2015 ; 13 (ä): ä Nephropedia Template TP {{tp|p=26174551|t=2015. IL-17/IL-10 double-producing T cells: new link between infections, immunosuppression and acute myeloid leukemia |pdf=|usr=}}{{26174551}} gab.com Text IL-17/IL-10 double-producing T cells: new link between infections, immunosuppression and acute myeloid leukemia JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26174551 #FOAvip Background: Acute myeloid leukemia (AML) is an incurable disease with fatal infections or relapse being the main causes of death in most cases. In particular, the severe infections occurring in these patients before or during any treatment suggest an intrinsic alteration of the immune system. In this respect, IL-17-producing T helper (Th17) besides playing a key role in regulating inflammatory response, tumor growth and autoimmune diseases, have been shown to protect against bacterial and fungal pathogens. However, the role of Th17 cells in AML has not yet been clarified. Methods: T cell frequencies were assessed by flow cytometry in the peripheral blood of 30 newly diagnosed AML patients and 30 age-matched healthy volunteers. Cytokine production was determined before and after culture of T cells with either Candida Albicans or AML blasts. Statistical analyses were carried out using the paired and unpaired two-tailed Student?s t tests and confirmed with the non parametric Wilcoxon signed-rank test. Results: A strong increase of Th17 cells producing immunosuppressive IL-10 was observed in AML patients compared with healthy donors. In addition, stimulation of AML-derived T cells with a Candida albicans antigen induced significantly lower IFN-? production than that observed in healthy donors; intriguingly, depletion of patient Th17 cells restored IFN-? production after stimulation. To address the role of AML blasts in inducing Th17 alterations, CD4+ cells from healthy donors were co-cultured with CD33+ blasts: data obtained showed that AML blasts induce in healthy donors levels of IL-10-producing Th17 cells similar to those observed in patients. Conclusions: In AML patients altered Th17 cells actively cause an immunosuppressive state that may promote infections and probably tumor escape. Th17 cells could thus represent a new target to improve AML immunotherapy. Twit Text FOAVip IL-17/IL-10 double-producing T cells: new link between infections, immunosuppression and acute myeloid leukemia ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26174551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26174551 #FOAvip English Wikipedia <ref>{{Cite pmid|26174551}}</ref> IL-17/IL-10 double-producing T cells: new link between infections, immunosuppression and acute myeloid leukemia #MMPMID26174551 Musuraca G; De Matteis S; Napolitano R; Papayannidis C; Guadagnuolo V; Fabbri F; Cangini D; Ceccolini M; Giannini MB; Lucchesi A; Ronconi S; Mariotti P; Savini P; Tani M; Fattori PP; Guidoboni M; Martinelli G; Zoli W; Amadori D; Carloni S J Transl Med 2015[]; 13 (ä): ä PMID26174551show ga Background: Acute myeloid leukemia (AML) is an incurable disease with fatal infections or relapse being the main causes of death in most cases. In particular, the severe infections occurring in these patients before or during any treatment suggest an intrinsic alteration of the immune system. In this respect, IL-17-producing T helper (Th17) besides playing a key role in regulating inflammatory response, tumor growth and autoimmune diseases, have been shown to protect against bacterial and fungal pathogens. However, the role of Th17 cells in AML has not yet been clarified. Methods: T cell frequencies were assessed by flow cytometry in the peripheral blood of 30 newly diagnosed AML patients and 30 age-matched healthy volunteers. Cytokine production was determined before and after culture of T cells with either Candida Albicans or AML blasts. Statistical analyses were carried out using the paired and unpaired two-tailed Student?s t tests and confirmed with the non parametric Wilcoxon signed-rank test. Results: A strong increase of Th17 cells producing immunosuppressive IL-10 was observed in AML patients compared with healthy donors. In addition, stimulation of AML-derived T cells with a Candida albicans antigen induced significantly lower IFN-? production than that observed in healthy donors; intriguingly, depletion of patient Th17 cells restored IFN-? production after stimulation. To address the role of AML blasts in inducing Th17 alterations, CD4+ cells from healthy donors were co-cultured with CD33+ blasts: data obtained showed that AML blasts induce in healthy donors levels of IL-10-producing Th17 cells similar to those observed in patients. Conclusions: In AML patients altered Th17 cells actively cause an immunosuppressive state that may promote infections and probably tumor escape. Th17 cells could thus represent a new target to improve AML immunotherapy. äIL-17/IL-10 double-producing T cells: new link between infections, imm(epmc).pdf DeepDyve Pubget Overpricing