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10.4161/auto.36183 http://scihub22266oqcxt.onion/10.4161/auto.36183 C4502762!4502762!25484093     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2014 ; 10 (11): 1978-88 Nephropedia Template TP {{tp|p=25484093|t=2014. Acidocalcisome is required for autophagy in Trypanosoma brucei |pdf=|usr=}}{{25484093}} gab.com Text Acidocalcisome is required for autophagy in Trypanosoma brucei JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25484093 #FOAvip Lysosomes play important roles in autophagy, not only in autophagosome degradation, but also in autophagy initiation. In Trypanosoma brucei, an early divergent protozoan parasite, we discovered a previously unappreciated function of the acidocalcisome, a lysosome-related organelle characterized by acidic pH and large content of Ca2+ and polyphosphates, in autophagy regulation. Starvation- and chemical-induced autophagy is accompanied with acidocalcisome acidification, and blocking the acidification completely inhibits autophagosome formation. Blocking acidocalcisome biogenesis by depleting the adaptor protein-3 complex, which does not affect lysosome biogenesis or function, also inhibits autophagy. Overall, our results support the role of the acidocalcisome, a conserved organelle from bacteria to human, as a relevant regulator in autophagy. Twit Text FOAVip Acidocalcisome is required for autophagy in Trypanosoma brucei ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25484093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25484093 #FOAvip English Wikipedia <ref>{{Cite pmid|25484093}}</ref> Acidocalcisome is required for autophagy in Trypanosoma brucei #MMPMID25484093 Li FJ; He CY Autophagy 2014[Nov]; 10 (11): 1978-88 PMID25484093show ga Lysosomes play important roles in autophagy, not only in autophagosome degradation, but also in autophagy initiation. In Trypanosoma brucei, an early divergent protozoan parasite, we discovered a previously unappreciated function of the acidocalcisome, a lysosome-related organelle characterized by acidic pH and large content of Ca2+ and polyphosphates, in autophagy regulation. Starvation- and chemical-induced autophagy is accompanied with acidocalcisome acidification, and blocking the acidification completely inhibits autophagosome formation. Blocking acidocalcisome biogenesis by depleting the adaptor protein-3 complex, which does not affect lysosome biogenesis or function, also inhibits autophagy. Overall, our results support the role of the acidocalcisome, a conserved organelle from bacteria to human, as a relevant regulator in autophagy. äAcidocalcisome is required for autophagy in Trypanosoma brucei (epmc).pdf DeepDyve Pubget Overpricing