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10.7150/ijms.12164 http://scihub22266oqcxt.onion/10.7150/ijms.12164 C4502056!4502056 !26180508     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26180508 &cmd=llinks): Failed to open stream: HTTP request failed! 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Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease |pdf=|usr=}}{{26180508 }} gab.com Text Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease JO: Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=26180508 #FOAvip BACKGROUND: Compliance index derived from digital volume pulse (CI-DVP), measuring the relationship between volume and pressure changes in fingertip, is a surrogate marker of peripheral arterial stiffness. This study investigated if CI-DVP can predict renal function deterioration, cardiovascular events and mortality in patients with chronic kidney disease (CKD). METHODS: In this prospective observational study, 149 CKD patients were included for final analysis. CI-DVP and brachial-ankle pulse wave velocity (baPWV) were measured, decline in renal function was assessed by the estimated glomerular filtration rate (eGFR) slope. Composite renal and cardiovascular outcomes were evaluated, including ?50% eGFR decline, start of renal replacement therapy, and major adverse events. RESULTS: Patients in CKD stages 3b to 5 had higher baPWV and lower CI-DVP values than those in patients with CKD stages 1 to 3a. Stepwise multivariate linear regression analysis showed that lower CI-DVP (p =0.0001) and greater proteinuria (p =0.0023) were independent determinants of higher eGFR decline rate. Multivariate Cox regression analysis revealed that CI-DVP (HR 0.68, 95% CI 0.46-1.00), baseline eGFR (HR 0.96, 95% CI 0.94-0.98) and serum albumin (HR 0.17, 95% CI 0.07-0.42) were independent predictors for composite renal and cardiovascular outcomes. CONCLUSIONS: Compliance index, CI-DVP, was significantly associated with renal function decline in patients with CKD. A higher CI-DVP may have independent prognostic value in slower renal function decline and better composite renal and cardiovascular outcomes in CKD patients. Twit Text FOAVip Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease ????Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=26180508 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26180508 #FOAvip English Wikipedia <ref>{{Cite pmid|26180508 }}</ref> Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease #MMPMID26180508 Kuo TH ; Yang DC ; Lin WH ; Tseng CC ; Chen JY ; Ho CS ; Cheng MF ; Tsai WC ; Wang MC Int J Med Sci 2015[]; 12 (7 ): 530-7 PMID26180508 show ga BACKGROUND: Compliance index derived from digital volume pulse (CI-DVP), measuring the relationship between volume and pressure changes in fingertip, is a surrogate marker of peripheral arterial stiffness. This study investigated if CI-DVP can predict renal function deterioration, cardiovascular events and mortality in patients with chronic kidney disease (CKD). METHODS: In this prospective observational study, 149 CKD patients were included for final analysis. CI-DVP and brachial-ankle pulse wave velocity (baPWV) were measured, decline in renal function was assessed by the estimated glomerular filtration rate (eGFR) slope. Composite renal and cardiovascular outcomes were evaluated, including ?50% eGFR decline, start of renal replacement therapy, and major adverse events. RESULTS: Patients in CKD stages 3b to 5 had higher baPWV and lower CI-DVP values than those in patients with CKD stages 1 to 3a. Stepwise multivariate linear regression analysis showed that lower CI-DVP (p =0.0001) and greater proteinuria (p =0.0023) were independent determinants of higher eGFR decline rate. Multivariate Cox regression analysis revealed that CI-DVP (HR 0.68, 95% CI 0.46-1.00), baseline eGFR (HR 0.96, 95% CI 0.94-0.98) and serum albumin (HR 0.17, 95% CI 0.07-0.42) were independent predictors for composite renal and cardiovascular outcomes. CONCLUSIONS: Compliance index, CI-DVP, was significantly associated with renal function decline in patients with CKD. A higher CI-DVP may have independent prognostic value in slower renal function decline and better composite renal and cardiovascular outcomes in CKD patients. |*Prognosis [MESH] |*Vascular Stiffness [MESH] |Aged [MESH] |Ankle Brachial Index [MESH] |Biomarkers [MESH] |Blood Flow Velocity [MESH] |Female [MESH] |Glomerular Filtration Rate/physiology [MESH] |Humans [MESH] |Kidney/physiopathology [MESH] |Male [MESH] |Middle Aged [MESH] |Peripheral Arterial Disease/complications/*diagnosis/physiopathology [MESH] |Pulsatile Flow/physiology [MESH]Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predi(epmc).pdf DeepDyve Pubget Overpricing