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10.1016/j.clim.2015.01.002 http://scihub22266oqcxt.onion/10.1016/j.clim.2015.01.002 C4501913!4501913!25596453     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2017 ; 178 (ä): 1-9 Nephropedia Template TP {{tp|p=25596453|t=2017. Clonal and constricted T cell repertoire in Common Variable Immune Deficiency |pdf=|usr=}}{{25596453}} gab.com Text Clonal and constricted T cell repertoire in Common Variable Immune Deficiency JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25596453 #FOAvip We used high throughput sequencing to examine the structure and composition of the T cell receptor ? chain in Common Variable Immune Deficiency (CVID). TCR? CDR3 regions were amplified and sequenced from genomic DNA of 44 adult CVID subjects and 22 healthy adults, using a high-throughput multiplex PCR. CVID TCRs had significantly less junctional diversity, fewer n-nucleotide insertions and deletions, and completely lacked a population of highly modified TCRs, with 13 or more V-gene nucleotide deletions, seen in healthy controls. The CVID CDR3 sequences were significantly more clonal than control DNA, and displayed unique V gene usage. Despite reduced junctional diversity, increased clonality and similar infectious exposures, DNA of CVID subjects shared fewer TCR sequences as compared to controls. These abnormalities are pervasive, found in out-of-frame sequences and thus independent of selection and were not associated with specific clinical complications. These data support an inherent T cell defect in CVID. Twit Text FOAVip Clonal and constricted T cell repertoire in Common Variable Immune Deficiency ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25596453 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25596453 #FOAvip English Wikipedia <ref>{{Cite pmid|25596453}}</ref> Clonal and constricted T cell repertoire in Common Variable Immune Deficiency #MMPMID25596453 Ramesh M; Hamm D; Simchoni N; Cunningham-Rundles C Clin Immunol 2017[May]; 178 (ä): 1-9 PMID25596453show ga We used high throughput sequencing to examine the structure and composition of the T cell receptor ? chain in Common Variable Immune Deficiency (CVID). TCR? CDR3 regions were amplified and sequenced from genomic DNA of 44 adult CVID subjects and 22 healthy adults, using a high-throughput multiplex PCR. CVID TCRs had significantly less junctional diversity, fewer n-nucleotide insertions and deletions, and completely lacked a population of highly modified TCRs, with 13 or more V-gene nucleotide deletions, seen in healthy controls. The CVID CDR3 sequences were significantly more clonal than control DNA, and displayed unique V gene usage. Despite reduced junctional diversity, increased clonality and similar infectious exposures, DNA of CVID subjects shared fewer TCR sequences as compared to controls. These abnormalities are pervasive, found in out-of-frame sequences and thus independent of selection and were not associated with specific clinical complications. These data support an inherent T cell defect in CVID. äClonal and constricted T cell repertoire in Common Variable Immune Def(epmc).pdf DeepDyve Pubget Overpricing