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10.3892/ijmm.2015.2233 http://scihub22266oqcxt.onion/10.3892/ijmm.2015.2233 C4501647!4501647 !26046127     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26046127 &cmd=llinks): Failed to open stream: HTTP request failed! 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Urine and serum metabolomic profiling reveals that bile acids and carnitine may be potential biomarkers of primary biliary cirrhosis |pdf=|usr=}}{{26046127 }} gab.com Text Urine and serum metabolomic profiling reveals that bile acids and carnitine may be potential biomarkers of primary biliary cirrhosis JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26046127 #FOAvip In order to provide non-invasive, reliable and sensitive laboratory parameters for the diagnosis of primary biliary cirrhosis (PBC), metabolic technology of ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF MS) was used to compare small molecule metabolites in blood and urine from patients with PBC and healthy controls. We then screened for bio-markers in the blood and urine of the patients with PBC. Data were processed by Bruker ProfileAnalysis metabonomic software and imported to SIMCA-P software, which utilized principal component analysis (PCA) to create models of patients with PBC and healthy controls. In total, 18 urinary markers were found and the levels of 11 of these urinary markers were elevated in the patients with PBC, whereas the levels of the remaining 7 markers were lower in the PBC group compared to the control group. We also identified 20 blood-based biomarkers in the patients with PBC and the levels of 9 of these markers were higher in the PBC group, whereas the levels of the remaining 11 markers were lower in the patients with PBC compared to the controls. Among these biomarkers, the levels of bile acids increased with the progression of PBC, while the levels of carnitines, such as propionyl carnitine and butyryl carnitine, decreased with the progression of PBC. In conclusion, the findings of the present study suggest that the circulating levels of bile acids and carnitine are differentially altered in patients with PBC. Twit Text FOAVip Urine and serum metabolomic profiling reveals that bile acids and carnitine may be potential biomarkers of primary biliary cirrhosis ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26046127 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26046127 #FOAvip English Wikipedia <ref>{{Cite pmid|26046127 }}</ref> Urine and serum metabolomic profiling reveals that bile acids and carnitine may be potential biomarkers of primary biliary cirrhosis #MMPMID26046127 Tang YM ; Wang JP ; Bao WM ; Yang JH ; Ma LK ; Yang J ; Chen H ; Xu Y ; Yang LH ; Li W ; Zhu YP ; Cheng JB Int J Mol Med 2015[Aug]; 36 (2 ): 377-85 PMID26046127 show ga In order to provide non-invasive, reliable and sensitive laboratory parameters for the diagnosis of primary biliary cirrhosis (PBC), metabolic technology of ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF MS) was used to compare small molecule metabolites in blood and urine from patients with PBC and healthy controls. We then screened for bio-markers in the blood and urine of the patients with PBC. Data were processed by Bruker ProfileAnalysis metabonomic software and imported to SIMCA-P software, which utilized principal component analysis (PCA) to create models of patients with PBC and healthy controls. In total, 18 urinary markers were found and the levels of 11 of these urinary markers were elevated in the patients with PBC, whereas the levels of the remaining 7 markers were lower in the PBC group compared to the control group. We also identified 20 blood-based biomarkers in the patients with PBC and the levels of 9 of these markers were higher in the PBC group, whereas the levels of the remaining 11 markers were lower in the patients with PBC compared to the controls. Among these biomarkers, the levels of bile acids increased with the progression of PBC, while the levels of carnitines, such as propionyl carnitine and butyryl carnitine, decreased with the progression of PBC. In conclusion, the findings of the present study suggest that the circulating levels of bile acids and carnitine are differentially altered in patients with PBC. |*Metabolome [MESH] |Adult [MESH] |Aged [MESH] |Bile Acids and Salts/blood/metabolism/urine [MESH] |Biomarkers/blood/metabolism/urine [MESH] |Carnitine/analogs & derivatives/blood/metabolism/urine [MESH] |Chromatography, High Pressure Liquid/methods [MESH] |Female [MESH] |Humans [MESH] |Liver Cirrhosis, Biliary/*blood/metabolism/*urine [MESH] |Male [MESH] |Mass Spectrometry/methods [MESH] |Metabolomics/methods [MESH]Urine and serum metabolomic profiling reveals that bile acids and carn(epmc).pdf DeepDyve Pubget Overpricing