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10.1161/CIRCRESAHA.117.305109 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.117.305109 C4501273!4501273!26089364     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Circ+Res 2015 ; 117 (1): 65-79 Nephropedia Template TP {{tp|p=26089364|t=2015. HIF hydroxylase pathways in cardiovascular physiology and medicine |pdf=|usr=}}{{26089364}} gab.com Text HIF hydroxylase pathways in cardiovascular physiology and medicine JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=26089364 #FOAvip Hypoxia inducible factors (HIFs) are alpha/beta heterodimeric transcription factors that direct multiple cellular and systemic responses in response to changes in oxygen availability. The oxygen sensitive signal is generated by a series of iron and 2-oxoglutarate dependent dioxygenases that catalyse post-translational hydroxylation of specific prolyl and asparaginyl residues in HIFalpha subunits and thereby promote their destruction and inactivation in the presence of oxygen. In hypoxia, these processes are suppressed allowing HIF to activate a massive transcriptional cascade. Elucidation of these pathways has opened several new fields of cardiovascular research. Here we review the role of HIF hydroxylase pathways in cardiac development and in cardiovascular control. We also consider the current status, opportunities and challenges of therapeutic modulation of HIF hydroxylases in the therapy of cardiovascular disease. Twit Text FOAVip HIF hydroxylase pathways in cardiovascular physiology and medicine ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=26089364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26089364 #FOAvip English Wikipedia <ref>{{Cite pmid|26089364}}</ref> HIF hydroxylase pathways in cardiovascular physiology and medicine #MMPMID26089364 Bishop T; Ratcliffe PJ Circ Res 2015[Jun]; 117 (1): 65-79 PMID26089364show ga Hypoxia inducible factors (HIFs) are alpha/beta heterodimeric transcription factors that direct multiple cellular and systemic responses in response to changes in oxygen availability. The oxygen sensitive signal is generated by a series of iron and 2-oxoglutarate dependent dioxygenases that catalyse post-translational hydroxylation of specific prolyl and asparaginyl residues in HIFalpha subunits and thereby promote their destruction and inactivation in the presence of oxygen. In hypoxia, these processes are suppressed allowing HIF to activate a massive transcriptional cascade. Elucidation of these pathways has opened several new fields of cardiovascular research. Here we review the role of HIF hydroxylase pathways in cardiac development and in cardiovascular control. We also consider the current status, opportunities and challenges of therapeutic modulation of HIF hydroxylases in the therapy of cardiovascular disease. äHIF hydroxylase pathways in cardiovascular physiology and medicine (epmc).pdf DeepDyve Pubget Overpricing