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2015 ; 19
(1
): 281
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Urine sTREM-1 may be a valuable biomarker in diagnosis and prognosis of
sepsis-associated acute kidney injury
#MMPMID26169055
Su L
; Xie L
; Liu D
Crit Care
2015[Jul]; 19
(1
): 281
PMID26169055
show ga
Urine soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) has been
reported in sepsis diagnosis and prediction of sepsis-associated acute kidney
injury (AKI). However, the mechanisms of the role of sTREM-1 for AKI remain
unclear. It may be that topical inflammatory response of kidney, not just
systemic inflammation, contributes to the elevated secretion of urine sTREM-1 in
the process of sepsis-associated AKI. To further evaluate the role of sTREM-1 in
this process, a larger-cohort multicenter study and the relevant basic research
should be performed to reveal the diagnostic value and mechanism of sTREM-1
during the sepsis-associated AKI process. If successful, then urine sTREM-1 would
be a good marker for sepsis and its associated AKI and could contribute to
non-invasive diagnosis and monitoring in the clinical setting. Additionally,
owing to the complexity of the pathogenesis of sepsis, it is necessary to combine
some biomarkers to improve diagnostic performance in the diagnosis of
sepsis-associated AKI rather than relying on a single marker.