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10.1186/s13287-015-0103-4 http://scihub22266oqcxt.onion/10.1186/s13287-015-0103-4 C4501079!4501079!26076648     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Res+Ther 2015 ; 6 (1): ä Nephropedia Template TP {{tp|p=26076648|t=2015. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately |pdf=|usr=}}{{26076648}} gab.com Text Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately JO: Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26076648 #FOAvip Introduction: Wnt and Notch signaling pathways are critically involved in relative cell fate decisions within the development of cutaneous tissues. Moreover, several studies identified the above two pathways as having a significant role during wound healing. However, their biological effects during cutaneous tissues repair are unclear. Methods: We employed a self-controlled model (Sprague?Dawley rats with full-thickness skin wounds) to observe the action and effect of Wnt/?-catenin and Notch signalings in vivo. The quality of wound repair relevant to the gain/loss-of-function Wnt/?-catenin and Notch activation was estimated by hematoxylin-and-eosin and Masson staining. Immunofluorescence analysis and Western blot analysis were used to elucidate the underlying mechanism of the regulation of Wnt and Notch signaling pathways in wound healing. Meanwhile, epidermal stem cells (ESCs) were cultured in keratinocyte serum-free medium with Jaggedl or in DAPT (N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl) to investigate whether the interruption of Notch signaling contributes to the expression of Wnt/?-catenin signaling. Results: The results showed that in vivo the gain-of-function Wnt/?-catenin and Notch activation extended the ability to promote wound closure. We further determined that activation or inhibition of Wnt signaling and Notch signaling can affect the proliferation of ESCs, the differentiation and migration of keratinocytes, and follicle regeneration by targeting c-Myc and Hes1, which ultimately lead to enhanced or delayed wound healing. Furthermore, Western blot analysis suggested that the two pathways might interact in vivo and in vitro. Conclusion: These results suggest that Wnt and Notch signalings play important roles in cutaneous repair by targeting c-Myc and Hes1 separately. What?s more, interaction between the above two pathways might act as a vital role in regulation of wound healing. Twit Text FOAVip Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately ????Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26076648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26076648 #FOAvip English Wikipedia <ref>{{Cite pmid|26076648}}</ref> Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately #MMPMID26076648 Shi Y; Shu B; Yang R; Xu Y; Xing B; Liu J; Chen L; Qi S; Liu X; Wang P; Tang J; Xie J Stem Cell Res Ther 2015[]; 6 (1): ä PMID26076648show ga Introduction: Wnt and Notch signaling pathways are critically involved in relative cell fate decisions within the development of cutaneous tissues. Moreover, several studies identified the above two pathways as having a significant role during wound healing. However, their biological effects during cutaneous tissues repair are unclear. Methods: We employed a self-controlled model (Sprague?Dawley rats with full-thickness skin wounds) to observe the action and effect of Wnt/?-catenin and Notch signalings in vivo. The quality of wound repair relevant to the gain/loss-of-function Wnt/?-catenin and Notch activation was estimated by hematoxylin-and-eosin and Masson staining. Immunofluorescence analysis and Western blot analysis were used to elucidate the underlying mechanism of the regulation of Wnt and Notch signaling pathways in wound healing. Meanwhile, epidermal stem cells (ESCs) were cultured in keratinocyte serum-free medium with Jaggedl or in DAPT (N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl) to investigate whether the interruption of Notch signaling contributes to the expression of Wnt/?-catenin signaling. Results: The results showed that in vivo the gain-of-function Wnt/?-catenin and Notch activation extended the ability to promote wound closure. We further determined that activation or inhibition of Wnt signaling and Notch signaling can affect the proliferation of ESCs, the differentiation and migration of keratinocytes, and follicle regeneration by targeting c-Myc and Hes1, which ultimately lead to enhanced or delayed wound healing. Furthermore, Western blot analysis suggested that the two pathways might interact in vivo and in vitro. Conclusion: These results suggest that Wnt and Notch signalings play important roles in cutaneous repair by targeting c-Myc and Hes1 separately. What?s more, interaction between the above two pathways might act as a vital role in regulation of wound healing. äWnt and Notch signaling pathway involved in wound healing by targeting(epmc).pdf DeepDyve Pubget Overpricing