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http://scihub22266oqcxt.onion/ C4500934!4500934!23474563     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JOP 2013 ; 14 (2): 161-70 Nephropedia Template TP {{tp|p=23474563|t=2013. Urinary 1H-NMR Metabolomics Can Distinguish Pancreatitis Patients from Healthy Controls |pdf=|usr=}}{{23474563}} gab.com Text Urinary 1H-NMR Metabolomics Can Distinguish Pancreatitis Patients from Healthy Controls JO: JOP http://www.kidney.de/pget.php?&tw=1&pmid=23474563 #FOAvip Context: The characterization of the urinary metabolome may yield biomarkers indicative of pancreatitis. Objectives: We establish a non-invasive technique to compare urinary metabolic profiles in patients with acute and chronic pancreatitis to healthy controls. Methods: Urine was obtained from healthy controls (HC, n=5), in patients with mild acute pancreatitis (AP, n=5), and outpatients with chronic pancreatitis (CP, n=5). Proton nuclear magnetic resonance spectra were obtained for each sample. Metabolites were identified and quantified in each spectrum; resulting concentrations were normalized to account for differences in dilution among samples. Kruskal-Wallis test, post-hoc Mann-Whitney U tests, and principal component analysis were performed to identify metabolites that discriminate healthy controls, acute pancreatitis, and chronic pancreatitis. Results: Sixty metabolites were identified and quantified; five were found to differ significantly (P<0.05) among the three groups. Of these, citrate and adenosine remained significant after validation by random permutation. Principal component analysis demonstrated that healthy control urine samples can be differentiated from patients with chronic pancreatitis or acute pancreatitis; chronic pancreatitis patients could not be distinguished from acute pancreatitis patients. Conclusions: This metabolomic investigation demonstrates that this non-invasive technique offers insight into the metabolic states of pancreatitis. Although the identified metabolites cannot conclusively be defined as biomarkers of disease, future studies will validate our findings in larger patient cohorts. Twit Text FOAVip Urinary 1H-NMR Metabolomics Can Distinguish Pancreatitis Patients from Healthy Controls ????JOP http://www.kidney.de/pget.php?&tw=1&pmid=23474563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23474563 #FOAvip English Wikipedia <ref>{{Cite pmid|23474563}}</ref> Urinary 1H-NMR Metabolomics Can Distinguish Pancreatitis Patients from Healthy Controls #MMPMID23474563 Lusczek ER; Paulo JA; Saltzman JR; Kadiyala V; Banks PA; Beilman G; Conwell DL JOP 2013[Mar]; 14 (2): 161-70 PMID23474563show ga Context: The characterization of the urinary metabolome may yield biomarkers indicative of pancreatitis. Objectives: We establish a non-invasive technique to compare urinary metabolic profiles in patients with acute and chronic pancreatitis to healthy controls. Methods: Urine was obtained from healthy controls (HC, n=5), in patients with mild acute pancreatitis (AP, n=5), and outpatients with chronic pancreatitis (CP, n=5). Proton nuclear magnetic resonance spectra were obtained for each sample. Metabolites were identified and quantified in each spectrum; resulting concentrations were normalized to account for differences in dilution among samples. Kruskal-Wallis test, post-hoc Mann-Whitney U tests, and principal component analysis were performed to identify metabolites that discriminate healthy controls, acute pancreatitis, and chronic pancreatitis. Results: Sixty metabolites were identified and quantified; five were found to differ significantly (P<0.05) among the three groups. Of these, citrate and adenosine remained significant after validation by random permutation. Principal component analysis demonstrated that healthy control urine samples can be differentiated from patients with chronic pancreatitis or acute pancreatitis; chronic pancreatitis patients could not be distinguished from acute pancreatitis patients. Conclusions: This metabolomic investigation demonstrates that this non-invasive technique offers insight into the metabolic states of pancreatitis. Although the identified metabolites cannot conclusively be defined as biomarkers of disease, future studies will validate our findings in larger patient cohorts. äUrinary 1H-NMR Metabolomics Can Distinguish Pancreatitis Patients from(epmc).pdf DeepDyve Pubget Overpricing