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Embryonic?maternal cross-talk via exosomes: potential implications #MMPMID26185458
Saadeldin IM; Oh HJ; Lee BC
Stem Cells Cloning 2015[]; 8 (ä): 103-7 PMID26185458show ga
A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic?maternal cross-talk. In this mini-review, we focused on the exosomes, which are cell-derived vesicles of 30?100 nm in diameter, as a communicating language facilitating this dialog. These nanovesicles are secreted from pre-implantation embryos, oviduct epithelium, and endometrium as well as from the placenta, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes, and have pleiotropic effects on both embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this cross-talk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering the normal reproductive functions.