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2015 ; 10
(7
): e0132869
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Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in
Patients with IgA Nephropathy
#MMPMID26167688
Zhao Y
; Liu L
; Huang J
; Shi S
; Lv J
; Liu G
; Zhao M
; Zhang H
PLoS One
2015[]; 10
(7
): e0132869
PMID26167688
show ga
BACKGROUND: Focal segmental glomerulosclerosis (FSGS) lesions are similar in
characteristics to S lesions of the Oxford classification of IgA nephropathy
(IgAN) and may predict poor prognosis. In the present study, we aimed to explore
the association between plasma soluble urokinase receptor (suPAR) levels and S
lesions and podocytes damage in IgAN patients. METHODS: We enrolled 569 IgAN
patients with follow-up data and detected plasma suPAR levels at renal biopsy by
enzyme-linked immunosorbent assay. RESULTS: Plasma suPAR levels in IgAN patients
with or without S lesions did not differ significantly (P = 0.411). However,
suPAR levels were positively correlated with proteinuria (r = 0.202, P < 0.001),
and negatively correlated with estimated glomerular filtration rate (eGFR, r =
-0.236, P < 0.001). In the partial correlation to adjust for eGFR, plasma suPAR
levels remained positively correlated with proteinuria (r = 0.112, P = 0.023). In
a Cox proportional hazards model, higher levels of plasma suPAR were not
associated with poor renal outcome. Plasma suPAR levels of IgAN and primary FSGS
patients with nephrotic syndrome were not significantly different (P = 0.306).
Plasma suPAR levels in patients with extensive effacement of the epithelial cell
foot processes of glomerular podocytes were significantly higher than those with
segmental effacement on the basis of comparable eGFR (P = 0.036). CONCLUSIONS: In
IgAN patients, plasma suPAR levels were not associated with S lesions. However,
they were positively associated with proteinuria and negatively associated with
eGFR. In addition, plasma suPAR levels were positively associated with the
effacement degree of the foot processes, which might partially contribute to the
development of proteinuria in patients with IgAN.
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