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10.3797/scipharm.1407-16 http://scihub22266oqcxt.onion/10.3797/scipharm.1407-16 C4500538!4500538!26171320     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Pharm 2014 ; 82 (4): 709-21 Nephropedia Template TP {{tp|p=26171320|t=2014. Pioglitazone and Endothelial Dysfunction: Pleiotropic Effects and Possible Therapeutic Implications |pdf=|usr=}}{{26171320}} gab.com Text Pioglitazone and Endothelial Dysfunction: Pleiotropic Effects and Possible Therapeutic Implications JO: Sci Pharm http://www.kidney.de/pget.php?&tw=1&pmid=26171320 #FOAvip The vascular endothelium has a central role in the modulation of vascular tone with associated antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, and anticoagulant effects. This is primarily accomplished by the timely release of endothelial autacoids. On the other hand, endothelial dysfunction (ED) provoked by insulin resistance has been linked with reduced nitric oxide bioavailability, increased production of reactive oxygen species, and alterations of endothelial regeneration. Pioglitazone is classified as an insulin-sensitizing, anti-hyperglycemic agent. The mechanism of action associated with pioglitazone includes the activation of peroxisome proliferator-activated receptor-gamma with stable improvement in glycemic control in diabetic patients. Today, it is known that apart from the beneficial effects on glucose homeostasis, pioglitazone exerts several pleiotropic effects, including the improvement of ED. Thus, the aim of this article was to summarize the current knowledge related to signaling mechanisms of the pioglitazone-induced improvement or reversal of ED. The relevant clinical studies and possible therapeutic implications connected to pioglitazone-related action on the endothelium were analyzed too. Twit Text FOAVip Pioglitazone and Endothelial Dysfunction: Pleiotropic Effects and Possible Therapeutic Implications ????Sci Pharm http://www.kidney.de/pget.php?&tw=1&pmid=26171320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26171320 #FOAvip English Wikipedia <ref>{{Cite pmid|26171320}}</ref> Pioglitazone and Endothelial Dysfunction: Pleiotropic Effects and Possible Therapeutic Implications #MMPMID26171320 Radenkovi? M Sci Pharm 2014[Oct]; 82 (4): 709-21 PMID26171320show ga The vascular endothelium has a central role in the modulation of vascular tone with associated antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, and anticoagulant effects. This is primarily accomplished by the timely release of endothelial autacoids. On the other hand, endothelial dysfunction (ED) provoked by insulin resistance has been linked with reduced nitric oxide bioavailability, increased production of reactive oxygen species, and alterations of endothelial regeneration. Pioglitazone is classified as an insulin-sensitizing, anti-hyperglycemic agent. The mechanism of action associated with pioglitazone includes the activation of peroxisome proliferator-activated receptor-gamma with stable improvement in glycemic control in diabetic patients. Today, it is known that apart from the beneficial effects on glucose homeostasis, pioglitazone exerts several pleiotropic effects, including the improvement of ED. Thus, the aim of this article was to summarize the current knowledge related to signaling mechanisms of the pioglitazone-induced improvement or reversal of ED. The relevant clinical studies and possible therapeutic implications connected to pioglitazone-related action on the endothelium were analyzed too. äPioglitazone and Endothelial Dysfunction: Pleiotropic Effects and Poss(epmc).pdf DeepDyve Pubget Overpricing