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10.1113/jphysiol.2014.287714

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suck abstract from ncbi


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pmid25640301
      J+Physiol 2015 ; 593 (12 ): 2627-34
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  • Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology #MMPMID25640301
  • Pless SA ; Kim RY ; Ahern CA ; Kurata HT
  • J Physiol 2015[Jun]; 593 (12 ): 2627-34 PMID25640301 show ga
  • Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino acids into proteins. We also review insights into the function and pharmacology of voltage-gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.
  • |*Ion Channels/chemistry/physiology [MESH]
  • |Amino Acids/genetics [MESH]
  • |Animals [MESH]


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