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10.1073/pnas.1506960112 http://scihub22266oqcxt.onion/10.1073/pnas.1506960112 C4500285!4500285!26106163     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (27): 8415-20 Nephropedia Template TP {{tp|p=26106163|t=2015. Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization |pdf=|usr=}}{{26106163}} gab.com Text Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26106163 #FOAvip Accumulation of lipofuscin in the retinal pigment epithelium precedes retinal degenerations and dystrophies responsible for blindness-causing retinal diseases. The mechanism behind lipofuscin formation in the retina or in any tissue is poorly understood. Here we show in mice that the dimerization of vitamin A is responsible for triggering the formation of more than 50% of ocular lipofuscin. Replacing three hydrogen atoms on vitamin A with deuterium inhibits vitamin A dimerization, resulting in reduced lipofuscin and transcriptional normalization of genes associated with inflammation without compromising retinal function. Thus, vitamin A deuterated at the carbon 20 position provides a clinically amiable tool to prevent vitamin A dimerization in humans to assess whether impeding such dimerization might prevent retinal degenerations such as Stargardt disease and age-related macular degeneration. Twit Text FOAVip Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26106163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26106163 #FOAvip English Wikipedia <ref>{{Cite pmid|26106163}}</ref> Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization #MMPMID26106163 Charbel Issa P; Barnard AR; Herrmann P; Washington I; MacLaren RE Proc Natl Acad Sci U S A 2015[Jul]; 112 (27): 8415-20 PMID26106163show ga Accumulation of lipofuscin in the retinal pigment epithelium precedes retinal degenerations and dystrophies responsible for blindness-causing retinal diseases. The mechanism behind lipofuscin formation in the retina or in any tissue is poorly understood. Here we show in mice that the dimerization of vitamin A is responsible for triggering the formation of more than 50% of ocular lipofuscin. Replacing three hydrogen atoms on vitamin A with deuterium inhibits vitamin A dimerization, resulting in reduced lipofuscin and transcriptional normalization of genes associated with inflammation without compromising retinal function. Thus, vitamin A deuterated at the carbon 20 position provides a clinically amiable tool to prevent vitamin A dimerization in humans to assess whether impeding such dimerization might prevent retinal degenerations such as Stargardt disease and age-related macular degeneration. äRescue of the Stargardt phenotype in Abca4 knockout mice through inhib(epmc).pdf DeepDyve Pubget Overpricing