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10.1073/pnas.1507882112 http://scihub22266oqcxt.onion/10.1073/pnas.1507882112 C4500257!4500257!26080435     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (27): 8403-8 Nephropedia Template TP {{tp|p=26080435|t=2015. PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3 |pdf=|usr=}}{{26080435}} gab.com Text PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26080435 #FOAvip Prostate cancer has an unpredictable natural history: While most tumors are clinically indolent, some patients display lethal phenotypes. Serum prostate-specific antigen is the most often used test in prostate cancer but screening is controversial. Treatment options are limited for metastatic disease, hence the need for early diagnosis. Prostate cancer antigen 3 (PCA3), a long noncoding RNA, is the most specific biomarker identified and approved as a diagnostic test. However, its inherent biological function (if any) has remained elusive. We uncovered a negative transdominant oncogenic role for PCA3 that down-regulates an unrecognized tumor suppressor gene, PRUNE2 (a human homolog of the Drosophila prune gene) thereby promoting malignant cell growth. This work defines a unique biological function for PCA3 in prostate cancer. Twit Text FOAVip PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26080435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26080435 #FOAvip English Wikipedia <ref>{{Cite pmid|26080435}}</ref> PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3 #MMPMID26080435 Salameh A; Lee AK; Cardó-Vila M; Nunes DN; Efstathiou E; Staquicini FI; Dobroff AS; Marchiò S; Navone NM; Hosoya H; Lauer RC; Wen S; Salmeron CC; Hoang A; Newsham I; Lima LA; Carraro DM; Oliviero S; Kolonin MG; Sidman RL; Do KA; Troncoso P; Logothetis CJ; Brentani RR; Calin GA; Cavenee WK; Dias-Neto E; Pasqualini R; Arap W Proc Natl Acad Sci U S A 2015[Jul]; 112 (27): 8403-8 PMID26080435show ga Prostate cancer has an unpredictable natural history: While most tumors are clinically indolent, some patients display lethal phenotypes. Serum prostate-specific antigen is the most often used test in prostate cancer but screening is controversial. Treatment options are limited for metastatic disease, hence the need for early diagnosis. Prostate cancer antigen 3 (PCA3), a long noncoding RNA, is the most specific biomarker identified and approved as a diagnostic test. However, its inherent biological function (if any) has remained elusive. We uncovered a negative transdominant oncogenic role for PCA3 that down-regulates an unrecognized tumor suppressor gene, PRUNE2 (a human homolog of the Drosophila prune gene) thereby promoting malignant cell growth. This work defines a unique biological function for PCA3 in prostate cancer. äPRUNE2 is a human prostate cancer suppressor regulated by the intronic(epmc).pdf DeepDyve Pubget Overpricing