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10.1093/cercor/bhl006

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C4500121!4500121!16772313
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suck abstract from ncbi


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pmid16772313      Cereb+Cortex 2007 ; 17 (4): 951-61
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  • Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry #MMPMID16772313
  • Just MA; Cherkassky VL; Keller TA; Kana RK; Minshew NJ
  • Cereb Cortex 2007[Apr]; 17 (4): 951-61 PMID16772313show ga
  • The brain activation of a group of high-functioning autistic participants was measured using fMRI during the performance of a Tower of London task, in comparison to a control group matched with respect to IQ, age, and gender. The two groups generally activated the same cortical areas to similar degrees. However, there were three indications of underconnectivity in the group with autism. First, the degree of synchronization (i.e. the functional connectivity, or the correlation of the time series of the activation) between the frontal and parietal areas of activation was lower for the autistic than the control participants. Second, relevant parts of the corpus callosum, through which many of the bilaterally activated cortical areas communicate, were smaller in cross-sectional area in the autistic participants. Third, within the autism group but not within the control group, the size of the genu of the corpus callosum was correlated with frontal-parietal functional connectivity. These findings suggest that the neural basis of altered cognition in autism entails a lower degree of integration of information across certain cortical areas resulting from reduced intra-cortical connectivity. The results add support to a new theory of cortical underconnectivity in autism, which posits a deficit in integration of information at the neural and cognitive levels.
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