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10.1186/s13059-015-0705-2 http://scihub22266oqcxt.onion/10.1186/s13059-015-0705-2 C4499915!4499915!26169368     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Biol 2015 ; 16 (1): ä Nephropedia Template TP {{tp|p=26169368|t=2015. Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis |pdf=|usr=}}{{26169368}} gab.com Text Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis JO: Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=26169368 #FOAvip Background: Long non-coding RNAs (lncRNAs) are not translated into proteins and were initially considered to be part of the ?dark matter? of the genome. Recently, it has been shown that lncRNAs play a role in the recruitment of chromatin modifying complexes and can influence gene expression. However, it is unknown if lncRNAs function in a similar way in cancer. Results: Here, we show that the lncRNA ROR occupies and activates the TESC promoter by repelling the histone G9A methyltransferase and promoting the release of histone H3K9 methylation. Suppression of ROR in tumors results in silencing of TESC expression, and G9A-mediated histone H3K9 methylation in the TESC promoter is restored, which significantly reduces tumor growth and metastasis. Without ROR silencing, TESC knockdown presents consistent and significant reductions in tumor progression. Conclusions: Our results reveal a novel mechanism by which ROR may serve as a decoy oncoRNA that blocks binding surfaces, preventing the recruitment of histone modifying enzymes, thereby specifying a new pattern of histone modifications that promote tumorigenesis. Electronic supplementary material: The online version of this article (doi:10.1186/s13059-015-0705-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis ????Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=26169368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26169368 #FOAvip English Wikipedia <ref>{{Cite pmid|26169368}}</ref> Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis #MMPMID26169368 Fan J; Xing Y; Wen X; Jia R; Ni H; He J; Ding X; Pan H; Qian G; Ge S; Hoffman AR; Zhang H; Fan X Genome Biol 2015[]; 16 (1): ä PMID26169368show ga Background: Long non-coding RNAs (lncRNAs) are not translated into proteins and were initially considered to be part of the ?dark matter? of the genome. Recently, it has been shown that lncRNAs play a role in the recruitment of chromatin modifying complexes and can influence gene expression. However, it is unknown if lncRNAs function in a similar way in cancer. Results: Here, we show that the lncRNA ROR occupies and activates the TESC promoter by repelling the histone G9A methyltransferase and promoting the release of histone H3K9 methylation. Suppression of ROR in tumors results in silencing of TESC expression, and G9A-mediated histone H3K9 methylation in the TESC promoter is restored, which significantly reduces tumor growth and metastasis. Without ROR silencing, TESC knockdown presents consistent and significant reductions in tumor progression. Conclusions: Our results reveal a novel mechanism by which ROR may serve as a decoy oncoRNA that blocks binding surfaces, preventing the recruitment of histone modifying enzymes, thereby specifying a new pattern of histone modifications that promote tumorigenesis. Electronic supplementary material: The online version of this article (doi:10.1186/s13059-015-0705-2) contains supplementary material, which is available to authorized users. äLong non-coding RNA ROR decoys gene-specific histone methylation to pr(epmc).pdf DeepDyve Pubget Overpricing