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10.1136/bcr-2015-210189

http://scihub22266oqcxt.onion/10.1136/bcr-2015-210189
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suck abstract from ncbi


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pmid26160550      BMJ+Case+Rep 2015 ; 2015 (ä): ä
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  • Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide #MMPMID26160550
  • van Raalte DH; Goorden SM; Kemper EA; Brosens LAA; ten Kate RW
  • BMJ Case Rep 2015[]; 2015 (ä): ä PMID26160550show ga
  • Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis.
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