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2015 ; 2015
(ä): 837042
Nephropedia Template TP
gab.com Text
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English Wikipedia
Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism,
Bioavailability, and Biological Effects in Animal Models and Humans
#MMPMID26221416
Gambini J
; Inglés M
; Olaso G
; Lopez-Grueso R
; Bonet-Costa V
; Gimeno-Mallench L
; Mas-Bargues C
; Abdelaziz KM
; Gomez-Cabrera MC
; Vina J
; Borras C
Oxid Med Cell Longev
2015[]; 2015
(ä): 837042
PMID26221416
show ga
Plants containing resveratrol have been used effectively in traditional medicine
for over 2000 years. It can be found in some plants, fruits, and derivatives,
such as red wine. Therefore, it can be administered by either consuming these
natural products or intaking nutraceutical pills. Resveratrol exhibits a wide
range of beneficial properties, and this may be due to its molecular structure,
which endow resveratrol with the ability to bind to many biomolecules. Among
these properties its activity as an anticancer agent, a platelet antiaggregation
agent, and an antioxidant, as well as its antiaging, antifrailty,
anti-inflammatory, antiallergenic, and so forth activities, is worth
highlighting. These beneficial biological properties have been extensively
studied in humans and animal models, both in vitro and in vivo. The issue of
bioavailability of resveratrol is of paramount importance and is determined by
its rapid elimination and the fact that its absorption is highly effective, but
the first hepatic step leaves little free resveratrol. Clarifying aspects like
stability and pharmacokinetics of resveratrol metabolites would be fundamental to
understand and apply the therapeutic properties of resveratrol.