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10.1186/s12943-015-0361-x http://scihub22266oqcxt.onion/10.1186/s12943-015-0361-x C4498560!4498560 !26022660     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26022660 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cancer 2015 ; 14 (ä): 87 Nephropedia Template TP {{tp|p=26022660 |t=2015. The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses |pdf=|usr=}}{{26022660 }} gab.com Text The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses JO: Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26022660 #FOAvip Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by HPV infection is driven by the sustained expression of two oncogenes E6 and E7. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways that may be equally important for transformation. Among these pathways, the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signalling cascade plays a very important role in HPV-induced carcinogenesis by acting through multiple cellular and molecular events. In this review, we summarize the frequent amplification of PI3K/Akt/mTOR signals in HPV-induced cancers and discuss how HPV oncogenes E6/E7/E5 activate the PI3K/Akt/mTOR signalling pathway to modulate tumor initiation and progression and affect patient outcome. Improvement of our understanding of the mechanism by which the PI3K/Akt/mTOR signalling pathway contributes to the immortalization and carcinogenesis of HPV-transduced cells will assist in devising novel strategies for preventing and treating HPV-induced cancers. Twit Text FOAVip The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses ????Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26022660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26022660 #FOAvip English Wikipedia <ref>{{Cite pmid|26022660 }}</ref> The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses #MMPMID26022660 Zhang L ; Wu J ; Ling MT ; Zhao L ; Zhao KN Mol Cancer 2015[Apr]; 14 (ä): 87 PMID26022660 show ga Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by HPV infection is driven by the sustained expression of two oncogenes E6 and E7. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways that may be equally important for transformation. Among these pathways, the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signalling cascade plays a very important role in HPV-induced carcinogenesis by acting through multiple cellular and molecular events. In this review, we summarize the frequent amplification of PI3K/Akt/mTOR signals in HPV-induced cancers and discuss how HPV oncogenes E6/E7/E5 activate the PI3K/Akt/mTOR signalling pathway to modulate tumor initiation and progression and affect patient outcome. Improvement of our understanding of the mechanism by which the PI3K/Akt/mTOR signalling pathway contributes to the immortalization and carcinogenesis of HPV-transduced cells will assist in devising novel strategies for preventing and treating HPV-induced cancers. |*Signal Transduction [MESH] |Animals [MESH] |Ataxia Telangiectasia Mutated Proteins/metabolism [MESH] |Cell Transformation, Viral [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/metabolism [MESH] |Life Cycle Stages [MESH] |Neoplasms/*etiology/*metabolism [MESH] |Papillomaviridae/*physiology [MESH] |Papillomavirus Infections/*complications/virology [MESH] |Phosphatidylinositol 3-Kinases/*metabolism [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH] |TOR Serine-Threonine Kinases/*metabolism [MESH]The role of the PI3K/Akt/mTOR signalling pathway in human cancers indu(epmc).pdf DeepDyve Pubget Overpricing