BMJ Clin Evid 2015[]; 2015 (ä): ä PMIDC4498496show ga
Introduction: External genital warts (EGWs) are sexually transmitted benign epidermal growths caused by the human papillomavirus (HPV), on the anogenital areas of both women and men, as well as, occasionally, in other locations. In the US, about 50% to 60% of sexually active women aged 18 to 25 years have been exposed to HPV infection, but only 10% to 15% will have genital warts. Methods and outcomes: We conducted a systematic overview, aiming to answer the following clinical questions: What are the effects of ablative procedure (cryotherapy, laser therapy, electrosurgery, surgical excision) plus imiquimod in people with external genital warts? What are the effects of treatments for external genital warts in pregnancy? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2014 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). Results: At this update, searching of electronic databases retrieved 170 studies. After deduplication and removal of conference abstracts, 98 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 55 studies and the further review of 43 full publications. Of the 43 full articles evaluated, one systematic review and one RCT were added at this update. We performed a GRADE evaluation for two PICO combinations. Conclusions: In this systematic overview we present information relating to the effectiveness and safety of the following interventions: ablative procedure plus imiquimod; bi- and trichloroacetic acid; cryotherapy; electrosurgery; imiquimod alone; laser surgery; podophyllin; podophyllotoxin; and surgical excision.
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BMJ+Clin+Evid 2015 ; 2015 (ä): ä
