Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26199613
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Neural+Regen+Res
2015 ; 10
(6
): 951-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Neuroprotective effect of rapamycin on spinal cord injury via activation of the
Wnt/?-catenin signaling pathway
#MMPMID26199613
Gao K
; Wang YS
; Yuan YJ
; Wan ZH
; Yao TC
; Li HH
; Tang PF
; Mei XF
Neural Regen Res
2015[Jun]; 10
(6
): 951-7
PMID26199613
show ga
The Wnt/?-catenin signaling pathway plays a crucial role in neural development,
axonal guidance, neuropathic pain remission and neuronal survival. In this study,
we initially examined the effect of rapamycin on the Wnt/?-catenin signaling
pathway after spinal cord injury, by intraperitoneally injecting spinal cord
injured rats with rapamycin over 2 days. Western blot analysis and
immunofluorescence staining were used to detect the expression levels of
?-catenin protein, caspase-3 protein and brain-derived neurotrophic factor
protein, components of the Wnt/?-catenin signaling pathway. Rapamycin increased
the levels of ?-catenin and brain-derived neurotrophic factor in the injured
spinal cord, improved the pathological morphology at the injury site, reduced the
loss of motor neurons, and promoted motor functional recovery in rats after
spinal cord injury. Our experimental findings suggest that the neuroprotective
effect of rapamycin intervention is mediated through activation of the
Wnt/?-catenin signaling pathway after spinal cord injury.