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10.1038/ncomms8566 http://scihub22266oqcxt.onion/10.1038/ncomms8566 C4498267!4498267!26151823     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26151823|t=2015. Spontaneous restoration of transplantation tolerance after acute rejection |pdf=|usr=}}{{26151823}} gab.com Text Spontaneous restoration of transplantation tolerance after acute rejection JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26151823 #FOAvip Transplantation is a cure for end-stage organ failure but, in the absence of pharmacological immunosuppression, allogeneic organs are acutely rejected. Such rejection invariably results in allosensitization and accelerated rejection of secondary donor-matched grafts. Transplantation tolerance can be induced in animals and a subset of humans, and enables long-term acceptance of allografts without maintenance immunosuppression. However, graft rejection can occur long after a state of transplantation tolerance has been acquired. When such an allograft is rejected, it has been assumed that the same rules of allosensitization apply as to non-tolerant hosts and that immunological tolerance is permanently lost. Using a mouse model of cardiac transplantation, we show that when Listeria monocytogenes infection precipitates acute rejection, thus abrogating transplantation tolerance, the donor-specific tolerant state re-emerges, allowing spontaneous acceptance of a donor-matched second transplant. These data demonstrate a setting in which the memory of allograft tolerance dominates over the memory of transplant rejection. Twit Text FOAVip Spontaneous restoration of transplantation tolerance after acute rejection ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26151823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26151823 #FOAvip English Wikipedia <ref>{{Cite pmid|26151823}}</ref> Spontaneous restoration of transplantation tolerance after acute rejection #MMPMID26151823 Miller ML; Daniels MD; Wang T; Chen J; Young J; Xu J; Wang Y; Yin D; Vu V; Husain AN; Alegre ML; Chong AS Nat Commun 2015[]; 6 (ä): ä PMID26151823show ga Transplantation is a cure for end-stage organ failure but, in the absence of pharmacological immunosuppression, allogeneic organs are acutely rejected. Such rejection invariably results in allosensitization and accelerated rejection of secondary donor-matched grafts. Transplantation tolerance can be induced in animals and a subset of humans, and enables long-term acceptance of allografts without maintenance immunosuppression. However, graft rejection can occur long after a state of transplantation tolerance has been acquired. When such an allograft is rejected, it has been assumed that the same rules of allosensitization apply as to non-tolerant hosts and that immunological tolerance is permanently lost. Using a mouse model of cardiac transplantation, we show that when Listeria monocytogenes infection precipitates acute rejection, thus abrogating transplantation tolerance, the donor-specific tolerant state re-emerges, allowing spontaneous acceptance of a donor-matched second transplant. These data demonstrate a setting in which the memory of allograft tolerance dominates over the memory of transplant rejection. äSpontaneous restoration of transplantation tolerance after acute rejec(epmc).pdf DeepDyve Pubget Overpricing