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10.1016/j.immuni.2015.05.016 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.05.016 C4498255!4498255 !26084024     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26084024 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2015 ; 42 (6 ): 1062-74 Nephropedia Template TP {{tp|p=26084024 |t=2015. E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1? to Maintain Regulatory T Cell Stability and Suppressive Capacity |pdf=|usr=}}{{26084024 }} gab.com Text E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1 to Maintain Regulatory T Cell Stability and Suppressive Capacity JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26084024 #FOAvip Foxp3(+) regulatory T (Treg) cells play a critical role in immune homeostasis; however, the mechanisms to maintain their function remain unclear. Here, we report that the E3 ubiquitin ligase VHL is essential for Treg cell function. Mice with Foxp3-restricted VHL deletion displayed massive inflammation associated with excessive Treg cell interferon-? (IFN-?) production. VHL-deficient Treg cells failed to prevent colitis induction, but converted into Th1-like effector T cells. VHL intrinsically orchestrated such conversion under both steady and inflammatory conditions followed by Foxp3 downregulation, which was reversed by IFN-? deficiency. Augmented hypoxia-inducible factor 1? (HIF-1?)-induced glycolytic reprogramming was required for IFN-? production. Furthermore, HIF-1? bound directly to the Ifng promoter. HIF-1? knockdown or knockout could reverse the increased IFN-? by VHL-deficient Treg cells and restore their suppressive function in vivo. These findings indicate that regulation of HIF-1? pathway by VHL is crucial to maintain the stability and suppressive function of Foxp3(+) T cells. Twit Text FOAVip E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1 to Maintain Regulatory T Cell Stability and Suppressive Capacity ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26084024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26084024 #FOAvip English Wikipedia <ref>{{Cite pmid|26084024 }}</ref> E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1? to Maintain Regulatory T Cell Stability and Suppressive Capacity #MMPMID26084024 Lee JH ; Elly C ; Park Y ; Liu YC Immunity 2015[Jun]; 42 (6 ): 1062-74 PMID26084024 show ga Foxp3(+) regulatory T (Treg) cells play a critical role in immune homeostasis; however, the mechanisms to maintain their function remain unclear. Here, we report that the E3 ubiquitin ligase VHL is essential for Treg cell function. Mice with Foxp3-restricted VHL deletion displayed massive inflammation associated with excessive Treg cell interferon-? (IFN-?) production. VHL-deficient Treg cells failed to prevent colitis induction, but converted into Th1-like effector T cells. VHL intrinsically orchestrated such conversion under both steady and inflammatory conditions followed by Foxp3 downregulation, which was reversed by IFN-? deficiency. Augmented hypoxia-inducible factor 1? (HIF-1?)-induced glycolytic reprogramming was required for IFN-? production. Furthermore, HIF-1? bound directly to the Ifng promoter. HIF-1? knockdown or knockout could reverse the increased IFN-? by VHL-deficient Treg cells and restore their suppressive function in vivo. These findings indicate that regulation of HIF-1? pathway by VHL is crucial to maintain the stability and suppressive function of Foxp3(+) T cells. |Animals [MESH] |Cells, Cultured [MESH] |Cellular Reprogramming/genetics [MESH] |Colitis/*immunology [MESH] |Down-Regulation/genetics [MESH] |Forkhead Transcription Factors/genetics/metabolism [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism [MESH] |Immune Tolerance [MESH] |Inflammation/genetics [MESH] |Interferon-gamma/genetics/metabolism [MESH] |Lymphocyte Activation/genetics [MESH] |Mice [MESH] |Mice, Inbred Strains [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |RNA, Small Interfering/genetics [MESH] |T-Lymphocytes, Regulatory/*immunology [MESH] |Th1 Cells/*immunology [MESH]E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1? to Maint(epmc).pdf DeepDyve Pubget Overpricing