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10.1038/srep12051

http://scihub22266oqcxt.onion/10.1038/srep12051
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C4498232!4498232!26159228
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suck abstract from ncbi


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pmid26159228      Sci+Rep 2015 ; 5 (ä): ä
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  • Ancient DNA sequence revealed by error-correcting codes #MMPMID26159228
  • Brandão MM; Spoladore L; Faria LCB; Rocha ASL; Silva-Filho MC; Palazzo R
  • Sci Rep 2015[]; 5 (ä): ä PMID26159228show ga
  • A previously described DNA sequence generator algorithm (DNA-SGA) using error-correcting codes has been employed as a computational tool to address the evolutionary pathway of the genetic code. The code-generated sequence alignment demonstrated that a residue mutation revealed by the code can be found in the same position in sequences of distantly related taxa. Furthermore, the code-generated sequences do not promote amino acid changes in the deviant genomes through codon reassignment. A Bayesian evolutionary analysis of both code-generated and homologous sequences of the Arabidopsis thaliana malate dehydrogenase gene indicates an approximately 1 MYA divergence time from the MDH code-generated sequence node to its paralogous sequences. The DNA-SGA helps to determine the plesiomorphic state of DNA sequences because a single nucleotide alteration often occurs in distantly related taxa and can be found in the alternative codon patterns of noncanonical genetic codes. As a consequence, the algorithm may reveal an earlier stage of the evolution of the standard code.
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