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10.1186/s40064-015-1128-y http://scihub22266oqcxt.onion/10.1186/s40064-015-1128-y C4498004!4498004!26185738     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Springerplus 2015 ; 4 (ä): ä Nephropedia Template TP {{tp|p=26185738|t=2015. Myocardial infarction models in NOD/Scid mice for cell therapy research: permanent ischemia vs ischemia?reperfusion |pdf=|usr=}}{{26185738}} gab.com Text Myocardial infarction models in NOD/Scid mice for cell therapy research: permanent ischemia vs ischemia reperfusion JO: Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26185738 #FOAvip Myocardial infarction animal studies are used to study disease mechanisms and new treatment options. Typically, myocardial infarction (MI) is induced by permanent occlusion of the left anterior descending artery. Since in MI patients coronary blood flow is often restored new experimental models better reflecting clinical practice are needed. Here, permanent ischemia MI (PI group) was compared with transient ischemia (45 min) (IR group) in immunodeficient NOD/Scid mice. Cardiac function, infarct size, wall thickness and total collagen deposition were significantly reduced only in PI mice. Cardiac inflammatory cells and serum cytokine levels were less dynamic in IR animals compared to PI. So although IR better reflects clinical practice, it is secondary to PI for investigating cell therapy, since it induces too little damage to provide a measurable therapeutic window. MI did result in significant changes in the inflammatory state, indicating this immunodeficient mouse strain is valuable to study human cell therapy.Electronic supplementary material: The online version of this article (doi:10.1186/s40064-015-1128-y) contains supplementary material, which is available to authorized users. Twit Text FOAVip Myocardial infarction models in NOD/Scid mice for cell therapy research: permanent ischemia vs ischemia reperfusion ????Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26185738 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26185738 #FOAvip English Wikipedia <ref>{{Cite pmid|26185738}}</ref> Myocardial infarction models in NOD/Scid mice for cell therapy research: permanent ischemia vs ischemia?reperfusion #MMPMID26185738 van Zuylen VL; den Haan MC; Roelofs H; Fibbe WE; Schalij MJ; Atsma DE Springerplus 2015[]; 4 (ä): ä PMID26185738show ga Myocardial infarction animal studies are used to study disease mechanisms and new treatment options. Typically, myocardial infarction (MI) is induced by permanent occlusion of the left anterior descending artery. Since in MI patients coronary blood flow is often restored new experimental models better reflecting clinical practice are needed. Here, permanent ischemia MI (PI group) was compared with transient ischemia (45 min) (IR group) in immunodeficient NOD/Scid mice. Cardiac function, infarct size, wall thickness and total collagen deposition were significantly reduced only in PI mice. Cardiac inflammatory cells and serum cytokine levels were less dynamic in IR animals compared to PI. So although IR better reflects clinical practice, it is secondary to PI for investigating cell therapy, since it induces too little damage to provide a measurable therapeutic window. MI did result in significant changes in the inflammatory state, indicating this immunodeficient mouse strain is valuable to study human cell therapy.Electronic supplementary material: The online version of this article (doi:10.1186/s40064-015-1128-y) contains supplementary material, which is available to authorized users. äMyocardial infarction models in NOD/Scid mice for cell therapy researc(epmc).pdf DeepDyve Pubget Overpricing