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Myocardial infarction models in NOD/Scid mice for cell therapy research:
permanent ischemia vs ischemia-reperfusion
#MMPMID26185738
van Zuylen VL
; den Haan MC
; Roelofs H
; Fibbe WE
; Schalij MJ
; Atsma DE
Springerplus
2015[]; 4
(?): 336
PMID26185738
show ga
Myocardial infarction animal studies are used to study disease mechanisms and new
treatment options. Typically, myocardial infarction (MI) is induced by permanent
occlusion of the left anterior descending artery. Since in MI patients coronary
blood flow is often restored new experimental models better reflecting clinical
practice are needed. Here, permanent ischemia MI (PI group) was compared with
transient ischemia (45 min) (IR group) in immunodeficient NOD/Scid mice. Cardiac
function, infarct size, wall thickness and total collagen deposition were
significantly reduced only in PI mice. Cardiac inflammatory cells and serum
cytokine levels were less dynamic in IR animals compared to PI. So although IR
better reflects clinical practice, it is secondary to PI for investigating cell
therapy, since it induces too little damage to provide a measurable therapeutic
window. MI did result in significant changes in the inflammatory state,
indicating this immunodeficient mouse strain is valuable to study human cell
therapy.
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