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10.1172/JCI80297 http://scihub22266oqcxt.onion/10.1172/JCI80297 C4497761!4497761!25915585     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (6): 2335-46 Nephropedia Template TP {{tp|p=25915585|t=2015. Neurovascular crosstalk between interneurons and capillaries is required for vision |pdf=|usr=}}{{25915585}} gab.com Text Neurovascular crosstalk between interneurons and capillaries is required for vision JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25915585 #FOAvip Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. For example, the architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. Here, using murine genetic models and cell ablation strategies, we have demonstrated that a subset of retinal interneurons, the amacrine and horizontal cells, form neurovascular units with capillaries in 2 of the 3 retinal vascular plexuses. Moreover, we determined that these cells are required for generating and maintaining the intraretinal vasculature through precise regulation of hypoxia-inducible and proangiogenic factors, and that amacrine and horizontal cell dysfunction induces alterations to the intraretinal vasculature and substantial visual deficits. These findings demonstrate that specific retinal interneurons and the intraretinal vasculature are highly interdependent, and loss of either or both elicits profound effects on photoreceptor survival and function. Twit Text FOAVip Neurovascular crosstalk between interneurons and capillaries is required for vision ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25915585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25915585 #FOAvip English Wikipedia <ref>{{Cite pmid|25915585}}</ref> Neurovascular crosstalk between interneurons and capillaries is required for vision #MMPMID25915585 Usui Y; Westenskow PD; Kurihara T; Aguilar E; Sakimoto S; Paris LP; Wittgrove C; Feitelberg D; Friedlander MS; Moreno SK; Dorrell MI; Friedlander M J Clin Invest 2015[Jun]; 125 (6): 2335-46 PMID25915585show ga Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. For example, the architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. Here, using murine genetic models and cell ablation strategies, we have demonstrated that a subset of retinal interneurons, the amacrine and horizontal cells, form neurovascular units with capillaries in 2 of the 3 retinal vascular plexuses. Moreover, we determined that these cells are required for generating and maintaining the intraretinal vasculature through precise regulation of hypoxia-inducible and proangiogenic factors, and that amacrine and horizontal cell dysfunction induces alterations to the intraretinal vasculature and substantial visual deficits. These findings demonstrate that specific retinal interneurons and the intraretinal vasculature are highly interdependent, and loss of either or both elicits profound effects on photoreceptor survival and function. äNeurovascular crosstalk between interneurons and capillaries is requir(epmc).pdf DeepDyve Pubget Overpricing