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10.1172/JCI78090 http://scihub22266oqcxt.onion/10.1172/JCI78090 C4497751!4497751!26030228     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (6): 2242-9 Nephropedia Template TP {{tp|p=26030228|t=2015. MicroRNA regulation of lymphocyte tolerance and autoimmunity |pdf=|usr=}}{{26030228}} gab.com Text MicroRNA regulation of lymphocyte tolerance and autoimmunity JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26030228 #FOAvip Understanding the cell-intrinsic cues that permit self-reactivity in lymphocytes, and therefore autoimmunity, requires an understanding of the transcriptional and posttranscriptional regulation of gene expression in these cells. In this Review, we address seminal and recent research on microRNA (miRNA) regulation of central and peripheral tolerance. Human and mouse studies demonstrate that the PI3K pathway is a critical point of miRNA regulation of immune cell development and function that affects the development of autoimmunity. We also discuss how miRNA expression profiling in human autoimmune diseases has inspired mechanistic studies of miRNA function in the pathogenesis of multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, and asthma. Twit Text FOAVip MicroRNA regulation of lymphocyte tolerance and autoimmunity ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26030228 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26030228 #FOAvip English Wikipedia <ref>{{Cite pmid|26030228}}</ref> MicroRNA regulation of lymphocyte tolerance and autoimmunity #MMPMID26030228 Simpson LJ; Ansel KM J Clin Invest 2015[Jun]; 125 (6): 2242-9 PMID26030228show ga Understanding the cell-intrinsic cues that permit self-reactivity in lymphocytes, and therefore autoimmunity, requires an understanding of the transcriptional and posttranscriptional regulation of gene expression in these cells. In this Review, we address seminal and recent research on microRNA (miRNA) regulation of central and peripheral tolerance. Human and mouse studies demonstrate that the PI3K pathway is a critical point of miRNA regulation of immune cell development and function that affects the development of autoimmunity. We also discuss how miRNA expression profiling in human autoimmune diseases has inspired mechanistic studies of miRNA function in the pathogenesis of multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, and asthma. äMicroRNA regulation of lymphocyte tolerance and autoimmunity (epmc).pdf DeepDyve Pubget Overpricing