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10.4161/21623945.2014.985020

http://scihub22266oqcxt.onion/10.4161/21623945.2014.985020
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C4497301!4497301!26257989
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suck abstract from ncbi


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pmid26257989      Adipocyte 2015 ; 4 (3): 212-6
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  • Role of amyloid ? in the induction of lipolysis and secretion of adipokines from human adipose tissue #MMPMID26257989
  • Wan Z; Mah D; Simtchouk S; Kluftinger A; Little JP
  • Adipocyte 2015[Jul]; 4 (3): 212-6 PMID26257989show ga
  • Amyloid-? (A?) peptide, which is generated from proteolytic cleavage of amyloid precursor protein (APP), is a key molecule involved in the pathology of Alzheimer disease. Both APP and A? peptides are expressed in adipose tissue, however it is currently unclear whether A? can affect the key functions of adipose tissue. We aimed to explore whether A? affected lipolysis and adipokine secretion in cultured human adipose tissue. We found that A?25?35, which contains the main functional domain of the A?, stimulated lipolysis via PKA and ERK1/2-dependent pathways and that A?25?35 induced leptin and IL-6 secretion. It is concluded that A? peptide exerts functional effects on adipose tissue that may lead to increased release of free fatty acids and pro-inflammatory adipokines.
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