Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adipocyte 2015 ; 4 (3): 212-6 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of amyloid ? in the induction of lipolysis and secretion of adipokines from human adipose tissue #MMPMID26257989
Wan Z; Mah D; Simtchouk S; Kluftinger A; Little JP
Adipocyte 2015[Jul]; 4 (3): 212-6 PMID26257989show ga
Amyloid-? (A?) peptide, which is generated from proteolytic cleavage of amyloid precursor protein (APP), is a key molecule involved in the pathology of Alzheimer disease. Both APP and A? peptides are expressed in adipose tissue, however it is currently unclear whether A? can affect the key functions of adipose tissue. We aimed to explore whether A? affected lipolysis and adipokine secretion in cultured human adipose tissue. We found that A?25?35, which contains the main functional domain of the A?, stimulated lipolysis via PKA and ERK1/2-dependent pathways and that A?25?35 induced leptin and IL-6 secretion. It is concluded that A? peptide exerts functional effects on adipose tissue that may lead to increased release of free fatty acids and pro-inflammatory adipokines.