Role of amyloid ? in the induction of lipolysis and secretion of adipokines from
human adipose tissue
#MMPMID26257989
Wan Z
; Mah D
; Simtchouk S
; Kluftinger A
; Little JP
Adipocyte
2015[Jul]; 4
(3
): 212-6
PMID26257989
show ga
Amyloid-? (A?) peptide, which is generated from proteolytic cleavage of amyloid
precursor protein (APP), is a key molecule involved in the pathology of Alzheimer
disease. Both APP and A? peptides are expressed in adipose tissue, however it is
currently unclear whether A? can affect the key functions of adipose tissue. We
aimed to explore whether A? affected lipolysis and adipokine secretion in
cultured human adipose tissue. We found that A?25-35, which contains the main
functional domain of the A?, stimulated lipolysis via PKA and ERK1/2-dependent
pathways and that A?25-35 induced leptin and IL-6 secretion. It is concluded that
A? peptide exerts functional effects on adipose tissue that may lead to increased
release of free fatty acids and pro-inflammatory adipokines.