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10.1155/2015/476805

http://scihub22266oqcxt.onion/10.1155/2015/476805
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C4496652!4496652!26199759
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suck abstract from ncbi


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pmid26199759      Leuk+Res+Treatment 2015 ; 2015 (ä): ä
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  • Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid #MMPMID26199759
  • Yves P; Stephane M; Rishika B; Christine D; Gérard P
  • Leuk Res Treatment 2015[]; 2015 (ä): ä PMID26199759show ga
  • We describe the clinical and biological features of ten patients with a survival superior to ten years (long survival), out of 175 patients diagnosed with Adult T-cell Leukemia/Lymphoma (ATL) in Martinique (1983?2013). There were 5 lymphoma and 5 chronic subtypes. Five of them (3 chronic, 2 lymphoma) had been treated with valproic acid (VA) for neurological disorders developed before or after ATL diagnosis, suggesting a beneficial role for VA as a histone deacetylase inhibitor (HDI) in ATL treatment. Total duration of uninterrupted VA treatment ranged from 8 to 37 years. Overall, the 175 incident ATL cases presented with a median survival of 5.43 months. The five VA-treated (VA+) patients presented with longer survival compared to VA treatment-free patients (VA?). For chronic subtypes, survival periods were of 213 months for 3 VA+ patients and of 33 months for 11 VA? patients (p = 0.023). For lymphoma subtypes, survival periods were of 144 months for 2 VA+ patients versus 6 months for 49 VA? patients (p = 0.0046). ATL cases with skin lesions, particularly lymphoma subtypes, had a longer survival (13.96 months) compared to those without skin lesions (6.06 months, p = 0.002). Eight out of the 10 patients presenting with long survival had skin lesions.
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