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2015 ; 2015
(ä): 476805
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Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival:
Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic
Acid
#MMPMID26199759
Yves P
; Stephane M
; Rishika B
; Christine D
; Gérard P
Leuk Res Treatment
2015[]; 2015
(ä): 476805
PMID26199759
show ga
We describe the clinical and biological features of ten patients with a survival
superior to ten years (long survival), out of 175 patients diagnosed with Adult
T-cell Leukemia/Lymphoma (ATL) in Martinique (1983-2013). There were 5 lymphoma
and 5 chronic subtypes. Five of them (3 chronic, 2 lymphoma) had been treated
with valproic acid (VA) for neurological disorders developed before or after ATL
diagnosis, suggesting a beneficial role for VA as a histone deacetylase inhibitor
(HDI) in ATL treatment. Total duration of uninterrupted VA treatment ranged from
8 to 37 years. Overall, the 175 incident ATL cases presented with a median
survival of 5.43 months. The five VA-treated (VA(+)) patients presented with
longer survival compared to VA treatment-free patients (VA(-)). For chronic
subtypes, survival periods were of 213 months for 3 VA(+) patients and of 33
months for 11 VA(-) patients (p = 0.023). For lymphoma subtypes, survival periods
were of 144 months for 2 VA(+) patients versus 6 months for 49 VA(-) patients (p
= 0.0046). ATL cases with skin lesions, particularly lymphoma subtypes, had a
longer survival (13.96 months) compared to those without skin lesions (6.06
months, p = 0.002). Eight out of the 10 patients presenting with long survival
had skin lesions.