Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

http://scihub22266oqcxt.onion/ C4496365!4496365!25826085     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (12): 10432-44 Nephropedia Template TP {{tp|p=25826085|t=2015. Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness |pdf=|usr=}}{{25826085}} gab.com Text Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25826085 #FOAvip Enforced expression of miR-34a eliminates cancer stem cells in some malignant tumors. Sirtuin-1 (SIRT1) is a direct target of miR-34a. Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24? breast cancer stem cells (BCSCs). MiR-34a overexpression and knockdown of SIRT1 decreased proportion of BSCSs and mammosphere formation. Expression of CSC markers, ALDH1, BMI1 and Nanog was decreased. In nude mice xenografts, stable expression of miR-34a and silencing of SIRT1 reduced tumor burden. Taken together, our results demonstrated that miR-34a inhibits proliferative potential of BCSCs in vitro and in vivo, at least partially by downregulating SIRT1. The miR-34a-SIRT1 axis may play role in self-renewal of BCSCs. Twit Text FOAVip Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25826085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25826085 #FOAvip English Wikipedia <ref>{{Cite pmid|25826085}}</ref> Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness #MMPMID25826085 Ma W; Xiao GG; Mao J; Lu Y; Song B; Wang L; Fan S; Fan P; Hou Z; Li J; Yu X; Wang B; Wang H; Wang H; Xu F; Li Y; Liu Q; Li L Oncotarget 2015[Apr]; 6 (12): 10432-44 PMID25826085show ga Enforced expression of miR-34a eliminates cancer stem cells in some malignant tumors. Sirtuin-1 (SIRT1) is a direct target of miR-34a. Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24? breast cancer stem cells (BCSCs). MiR-34a overexpression and knockdown of SIRT1 decreased proportion of BSCSs and mammosphere formation. Expression of CSC markers, ALDH1, BMI1 and Nanog was decreased. In nude mice xenografts, stable expression of miR-34a and silencing of SIRT1 reduced tumor burden. Taken together, our results demonstrated that miR-34a inhibits proliferative potential of BCSCs in vitro and in vivo, at least partially by downregulating SIRT1. The miR-34a-SIRT1 axis may play role in self-renewal of BCSCs. äDysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemnes(epmc).pdf DeepDyve Pubget Overpricing