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http://scihub22266oqcxt.onion/ C4496341!4496341!25823924     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (12): 10073-85 Nephropedia Template TP {{tp|p=25823924|t=2015. NF2 blocks Snail-mediated p53 suppression in mesothelioma |pdf=|usr=}}{{25823924}} gab.com Text NF2 blocks Snail-mediated p53 suppression in mesothelioma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25823924 #FOAvip Although asbestos causes malignant pleural mesothelioma (MPM), rising from lung mesothelium, the molecular mechanism has not been suggested until now. Extremely low mutation rate in classical tumor suppressor genes (such as p53 and pRb) and oncogenes (including Ras or myc) indicates that there would be MPM-specific carcinogenesis pathway. To address this, we treated silica to mimic mesothelioma carcinogenesis in mesothelioma and non-small cell lung cancer cell lines (NSCLC). Treatment of silica induced p-Erk and Snail through RKIP reduction. In addition, p53 and E-cadherin were decreased by silica-treatment. Elimination of Snail restored p53 expression. We found that NF2 (frequently deleted in MPM) inhibited Snail-mediated p53 suppression and was stabilized by RKIP. Importantly, GN25, an inhibitor of p53-Snail interaction, induced p53 and apoptosis. These results indicate that MPM can be induced by reduction of RKIP/NF2, which suppresses p53 through Snail. Thus, the p53-Snail binding inhibitor such as GN25 is a drug candidate for MPM. Twit Text FOAVip NF2 blocks Snail-mediated p53 suppression in mesothelioma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25823924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25823924 #FOAvip English Wikipedia <ref>{{Cite pmid|25823924}}</ref> NF2 blocks Snail-mediated p53 suppression in mesothelioma #MMPMID25823924 Cho JH; Lee SJ; Oh AY; Yoon MH; Woo TG; Park BJ Oncotarget 2015[Apr]; 6 (12): 10073-85 PMID25823924show ga Although asbestos causes malignant pleural mesothelioma (MPM), rising from lung mesothelium, the molecular mechanism has not been suggested until now. Extremely low mutation rate in classical tumor suppressor genes (such as p53 and pRb) and oncogenes (including Ras or myc) indicates that there would be MPM-specific carcinogenesis pathway. To address this, we treated silica to mimic mesothelioma carcinogenesis in mesothelioma and non-small cell lung cancer cell lines (NSCLC). Treatment of silica induced p-Erk and Snail through RKIP reduction. In addition, p53 and E-cadherin were decreased by silica-treatment. Elimination of Snail restored p53 expression. We found that NF2 (frequently deleted in MPM) inhibited Snail-mediated p53 suppression and was stabilized by RKIP. Importantly, GN25, an inhibitor of p53-Snail interaction, induced p53 and apoptosis. These results indicate that MPM can be induced by reduction of RKIP/NF2, which suppresses p53 through Snail. Thus, the p53-Snail binding inhibitor such as GN25 is a drug candidate for MPM. äNF2 blocks Snail-mediated p53 suppression in mesothelioma (epmc).pdf DeepDyve Pubget Overpricing