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10.18632/oncotarget.3301 http://scihub22266oqcxt.onion/10.18632/oncotarget.3301 C4496244!4496244 !25821127     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25821127 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (11 ): 9627-42 Nephropedia Template TP {{tp|p=25821127 |t=2015. Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data |pdf=|usr=}}{{25821127 }} gab.com Text Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25821127 #FOAvip Head and neck squamous cell carcinoma (HNSCC) is a disease with heterogeneous clinical behavior and response to therapies. Despite the introduction of multimodality treatment, 40-50% of patients with advanced disease recur. Therefore, there is an urgent need to improve the classification beyond the current parameters in clinical use to better stratify patients and the therapeutic approaches. Following a meta-analysis approach we built a large training set to whom we applied a Disease-Specific Genomic Analysis (DSGA) to identify the disease component embedded into the tumor data. Eleven independent microarray datasets were used as validation sets. Six different HNSCC subtypes that summarize the aberrant alterations occurring during tumor progression were identified. Based on their main biological characteristics and de-regulated signaling pathways, the subtypes were designed as immunoreactive, inflammatory, human papilloma virus (HPV)-like, classical, hypoxia associated, and mesenchymal. Our findings highlighted a more aggressive behavior for mesenchymal and hypoxia-associated subtypes. The Genomics Drug Sensitivity Project was used to identify potential associations with drug sensitivity and significant differences were observed among the six subtypes. To conclude, we report a robust molecularly defined subtype classification in HNSCC that can improve patient selection and pave the way to the development of appropriate therapeutic strategies. Twit Text FOAVip Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25821127 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25821127 #FOAvip English Wikipedia <ref>{{Cite pmid|25821127 }}</ref> Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data #MMPMID25821127 De Cecco L ; Nicolau M ; Giannoccaro M ; Daidone MG ; Bossi P ; Locati L ; Licitra L ; Canevari S Oncotarget 2015[Apr]; 6 (11 ): 9627-42 PMID25821127 show ga Head and neck squamous cell carcinoma (HNSCC) is a disease with heterogeneous clinical behavior and response to therapies. Despite the introduction of multimodality treatment, 40-50% of patients with advanced disease recur. Therefore, there is an urgent need to improve the classification beyond the current parameters in clinical use to better stratify patients and the therapeutic approaches. Following a meta-analysis approach we built a large training set to whom we applied a Disease-Specific Genomic Analysis (DSGA) to identify the disease component embedded into the tumor data. Eleven independent microarray datasets were used as validation sets. Six different HNSCC subtypes that summarize the aberrant alterations occurring during tumor progression were identified. Based on their main biological characteristics and de-regulated signaling pathways, the subtypes were designed as immunoreactive, inflammatory, human papilloma virus (HPV)-like, classical, hypoxia associated, and mesenchymal. Our findings highlighted a more aggressive behavior for mesenchymal and hypoxia-associated subtypes. The Genomics Drug Sensitivity Project was used to identify potential associations with drug sensitivity and significant differences were observed among the six subtypes. To conclude, we report a robust molecularly defined subtype classification in HNSCC that can improve patient selection and pave the way to the development of appropriate therapeutic strategies. |*Gene Expression Profiling [MESH] |Carcinoma, Squamous Cell/*classification/genetics/immunology/pathology/virology [MESH] |Cell Hypoxia/genetics [MESH] |Datasets as Topic [MESH] |Disease Progression [MESH] |Drug Resistance, Neoplasm/genetics [MESH] |Epithelial-Mesenchymal Transition/genetics [MESH] |Genes, MHC Class II [MESH] |Genetic Heterogeneity [MESH] |Head and Neck Neoplasms/*classification/genetics/immunology/pathology/virology [MESH] |Humans [MESH] |Inflammation [MESH] |Microarray Analysis [MESH] |Neoplasm Proteins/genetics [MESH] |Papillomaviridae/isolation & purification [MESH] |Papillomavirus Infections/genetics [MESH] |Smoking/genetics [MESH]Head and neck cancer subtypes with biological and clinical relevance: (epmc).pdf DeepDyve Pubget Overpricing