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http://scihub22266oqcxt.onion/ C4496216!4496216!25797253     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (11): 9271-83 Nephropedia Template TP {{tp|p=25797253|t=2015. The mitochondrial carrier SLC25A10 regulates cancer cell growth |pdf=|usr=}}{{25797253}} gab.com Text The mitochondrial carrier SLC25A10 regulates cancer cell growth JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25797253 #FOAvip Dysregulation of cell metabolism is critical for the growth properties of cancer cells. The purpose of this study was to understand the role of substrate transport across the mitochondrial membrane to sustain the metabolic shift and redox defense in cancer cells. Mitochondrial carrier SLC25A10 is up-regulated in a variety of tumors and is involved in regulating intracellular levels of reactive oxygen species. We show that knockdown of SLC25A10 in A549 cells changed the growth properties to a less malignant phenotype and casued increased glutamine dependency and sensitivity to oxidative stress. The metabolic alteration was linked to an energy metabolic shift from glycolysis to mitochondrial oxidative phosphorylation illustrated by increased expression of glutamate dehydrogenase, decreased expression of lactate dehydrogenase due to down-regulation of hypoxia inducible factor 1?. We identified effects on NADPH production linked to the growth changes observed in SLC25A10 knockdown cells, demonstrated by decreased NADPH production in cells deprived of glutamine. The contribution of SLC25A10 to reprogram cell metabolism and to regulate cell growth suggests SLC25A10 as a novel target for anti-cancer strategies. Twit Text FOAVip The mitochondrial carrier SLC25A10 regulates cancer cell growth ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25797253 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25797253 #FOAvip English Wikipedia <ref>{{Cite pmid|25797253}}</ref> The mitochondrial carrier SLC25A10 regulates cancer cell growth #MMPMID25797253 Zhou X; Paredes JA; Krishnan S; Curbo S; Karlsson A Oncotarget 2015[Apr]; 6 (11): 9271-83 PMID25797253show ga Dysregulation of cell metabolism is critical for the growth properties of cancer cells. The purpose of this study was to understand the role of substrate transport across the mitochondrial membrane to sustain the metabolic shift and redox defense in cancer cells. Mitochondrial carrier SLC25A10 is up-regulated in a variety of tumors and is involved in regulating intracellular levels of reactive oxygen species. We show that knockdown of SLC25A10 in A549 cells changed the growth properties to a less malignant phenotype and casued increased glutamine dependency and sensitivity to oxidative stress. The metabolic alteration was linked to an energy metabolic shift from glycolysis to mitochondrial oxidative phosphorylation illustrated by increased expression of glutamate dehydrogenase, decreased expression of lactate dehydrogenase due to down-regulation of hypoxia inducible factor 1?. We identified effects on NADPH production linked to the growth changes observed in SLC25A10 knockdown cells, demonstrated by decreased NADPH production in cells deprived of glutamine. The contribution of SLC25A10 to reprogram cell metabolism and to regulate cell growth suggests SLC25A10 as a novel target for anti-cancer strategies. äThe mitochondrial carrier SLC25A10 regulates cancer cell growth (epmc).pdf DeepDyve Pubget Overpricing