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http://scihub22266oqcxt.onion/ C4496215!4496215!25831237     free     free     free       Oncotarget 2015 ; 6 (11): 9257-70 Nephropedia Template TP {{tp|p=25831237|t=2015. miR-340 suppresses glioblastoma multiforme |pdf=|usr=}}{{25831237}} gab.com Text miR-340 suppresses glioblastoma multiforme JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25831237 #FOAvip Deregulation of microRNAs (miRs) contributes to tumorigenesis. Down-regulation of miR-340 is observed in multiple types of cancers. However, the biological function of miR-340 in glioblastoma multiforme (GBM) remains largely unknown. In the present study, we demonstrated that expression of miR-340 was downregulated in both glioma cell lines and tissues. Survival of GBM patients with high levels of miR-340 was significantly extended in comparison to patients expressing low miR-340 levels. Biological functional experiments showed that the restoration of miR-340 dramatically inhibited glioma cell proliferation, induced cell-cycle arrest and apoptosis, suppressed cell motility and promoted autophagy and terminal differentiation. Mechanistic studies disclosed that, miR-340 over-expression suppressed several oncogenes including p-AKT, EZH2, EGFR, BMI1 and XIAP. Furthermore, ROCK1 was validated as a direct functional target miR-340 and silencing of ROCK1 phenocopied the anti-tumor effect of mR-340. Our findings indicate an important role of miR-340 as a glioma killer, and suggest a potential prognosis biomarker and therapeutic target for GBM. Twit Text FOAVip miR-340 suppresses glioblastoma multiforme ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25831237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25831237 #FOAvip English Wikipedia <ref>{{Cite pmid|25831237}}</ref> miR-340 suppresses glioblastoma multiforme #MMPMID25831237 Huang D; Qiu S; Ge R; He L; Li M; Li Y; Peng Y Oncotarget 2015[Apr]; 6 (11): 9257-70 PMID25831237show ga Deregulation of microRNAs (miRs) contributes to tumorigenesis. Down-regulation of miR-340 is observed in multiple types of cancers. However, the biological function of miR-340 in glioblastoma multiforme (GBM) remains largely unknown. In the present study, we demonstrated that expression of miR-340 was downregulated in both glioma cell lines and tissues. Survival of GBM patients with high levels of miR-340 was significantly extended in comparison to patients expressing low miR-340 levels. Biological functional experiments showed that the restoration of miR-340 dramatically inhibited glioma cell proliferation, induced cell-cycle arrest and apoptosis, suppressed cell motility and promoted autophagy and terminal differentiation. Mechanistic studies disclosed that, miR-340 over-expression suppressed several oncogenes including p-AKT, EZH2, EGFR, BMI1 and XIAP. Furthermore, ROCK1 was validated as a direct functional target miR-340 and silencing of ROCK1 phenocopied the anti-tumor effect of mR-340. Our findings indicate an important role of miR-340 as a glioma killer, and suggest a potential prognosis biomarker and therapeutic target for GBM. ämiR-340 suppresses glioblastoma multiforme (epmc).pdf DeepDyve Pubget Overpricing