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10.18632/oncotarget.3515 http://scihub22266oqcxt.onion/10.18632/oncotarget.3515 C4496201!4496201 !25826087     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25826087 &cmd=llinks): Failed to open stream: HTTP request failed! 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Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms |pdf=|usr=}}{{25826087 }} gab.com Text Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25826087 #FOAvip Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer cells, particularly oral squamous cell carcinoma (OSCC) cells that cause most oral cancers. Here, we studied how a monoclonal antibody (NZ-1) and lectin (MASL) that target PDPN affect human OSCC cell motility and viability. Both reagents inhibited the migration of PDPN expressing OSCC cells at nanomolar concentrations before inhibiting cell viability at micromolar concentrations. In addition, both reagents induced mitochondrial membrane permeability transition to kill OSCC cells that express PDPN by caspase independent nonapoptotic necrosis. Furthermore, MASL displayed a surprisingly robust ability to target PDPN on OSCC cells within minutes of exposure, and significantly inhibited human OSCC dissemination in zebrafish embryos. Moreover, we report that human OSCC cells formed tumors that expressed PDPN in mice, and induced PDPN expression in infiltrating host murine cancer associated fibroblasts. Taken together, these data suggest that antibodies and lectins may be utilized to combat OSCC and other cancers that express PDPN. Twit Text FOAVip Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25826087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25826087 #FOAvip English Wikipedia <ref>{{Cite pmid|25826087 }}</ref> Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms #MMPMID25826087 Ochoa-Alvarez JA ; Krishnan H ; Pastorino JG ; Nevel E ; Kephart D ; Lee JJ ; Retzbach EP ; Shen Y ; Fatahzadeh M ; Baredes S ; Kalyoussef E ; Honma M ; Adelson ME ; Kaneko MK ; Kato Y ; Young MA ; Deluca-Rapone L ; Shienbaum AJ ; Yin K ; Jensen LD ; Goldberg GS Oncotarget 2015[Apr]; 6 (11 ): 9045-60 PMID25826087 show ga Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer cells, particularly oral squamous cell carcinoma (OSCC) cells that cause most oral cancers. Here, we studied how a monoclonal antibody (NZ-1) and lectin (MASL) that target PDPN affect human OSCC cell motility and viability. Both reagents inhibited the migration of PDPN expressing OSCC cells at nanomolar concentrations before inhibiting cell viability at micromolar concentrations. In addition, both reagents induced mitochondrial membrane permeability transition to kill OSCC cells that express PDPN by caspase independent nonapoptotic necrosis. Furthermore, MASL displayed a surprisingly robust ability to target PDPN on OSCC cells within minutes of exposure, and significantly inhibited human OSCC dissemination in zebrafish embryos. Moreover, we report that human OSCC cells formed tumors that expressed PDPN in mice, and induced PDPN expression in infiltrating host murine cancer associated fibroblasts. Taken together, these data suggest that antibodies and lectins may be utilized to combat OSCC and other cancers that express PDPN. |*Molecular Targeted Therapy [MESH] |Administration, Oral [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Antibodies, Monoclonal/immunology/*pharmacology/therapeutic use [MESH] |Antineoplastic Agents, Phytogenic/administration & dosage/*pharmacology/therapeutic use [MESH] |Carcinoma, Squamous Cell/*pathology/virology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Survival/drug effects [MESH] |Fibroblasts/pathology [MESH] |Humans [MESH] |Membrane Glycoproteins/*antagonists & inhibitors/immunology/physiology [MESH] |Membrane Potential, Mitochondrial/drug effects [MESH] |Mice [MESH] |Mouth Neoplasms/*pathology/virology [MESH] |Neoplasm Proteins/*antagonists & inhibitors/immunology/physiology [MESH] |Papillomaviridae/isolation & purification [MESH] |Papillomavirus Infections/pathology/virology [MESH] |Phytohemagglutinins/administration & dosage/*pharmacology/therapeutic use [MESH] |Xenograft Model Antitumor Assays [MESH]Antibody and lectin target podoplanin to inhibit oral squamous carcino(epmc).pdf DeepDyve Pubget Overpricing