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WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by
inducing MMP-9 and VEGF-C
#MMPMID25797250
Tang YL
; Liu X
; Gao SY
; Feng H
; Jiang YP
; Wang SS
; Yang J
; Jiang J
; Ma XR
; Tang YJ
; Chen Y
; Liang XH
Oncotarget
2015[Apr]; 6
(11
): 9031-44
PMID25797250
show ga
The wild-type p53 induced phosphatase 1 (WIP1) is an oncogene overexpressed in a
variety of human cancers. Here, we demonstrated that WIP1 silencing reduced MMP-9
and VEGF-C expression as well as migration and invasion of salivary adenoid
cystic carcinoma (ACC) cells. Overexpression of MMP-9 or VEGF-C restored
migration and invasion in WIP1 knockdown cells, indicating that MMP-9 and VEGF-C
are downstream targets of WIP1 signaling. Levels of cyclin D1 and c-Myc, targets
of Wnt/?-catenin pathway, were significantly decreased by WIP1 silencing. In
addition, WIP1 expression was positively associated with metastasis and prognosis
of ACC patients as well as with MMP-9 or VEGF-C in ACC tissues.
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