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http://scihub22266oqcxt.onion/ C4496190!4496190!25749207     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (11): 8890-9 Nephropedia Template TP {{tp|p=25749207|t=2015. Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry |pdf=|usr=}}{{25749207}} gab.com Text Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25749207 #FOAvip Vasculogenic mimicry (VM) is a functional microcirculation formed by tumor cells. Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, promote VM formation. Another specific MMP, collagenase-3 (MMP-13), has broad substrate specificity and potentially affects tumor metastasis and invasion. Here we found that MMP-13 was associated with metastasis and poor survival in 79 patients with melanoma. MMP-13 expression was inversely correlated with VM. These results were confirmed in human and mouse melanoma cell lines. We found that MMP-13 cleaves laminin-5 (Ln-5) into small fragments to accelerate tumor metastasis. Degradation of Ln-5 and VE-cadherin by MMP-13 inhibited VM formation. In conclusion, MMP-13 has a dual effect in melanoma, as it promotes invasion and metastasis but disrupts VM formation. Twit Text FOAVip Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25749207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25749207 #FOAvip English Wikipedia <ref>{{Cite pmid|25749207}}</ref> Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry #MMPMID25749207 Zhao X; Sun B; Li Y; Liu Y; Zhang D; Wang X; Gu Q; Zhao J; Dong X; Liu Z; Che N Oncotarget 2015[Apr]; 6 (11): 8890-9 PMID25749207show ga Vasculogenic mimicry (VM) is a functional microcirculation formed by tumor cells. Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, promote VM formation. Another specific MMP, collagenase-3 (MMP-13), has broad substrate specificity and potentially affects tumor metastasis and invasion. Here we found that MMP-13 was associated with metastasis and poor survival in 79 patients with melanoma. MMP-13 expression was inversely correlated with VM. These results were confirmed in human and mouse melanoma cell lines. We found that MMP-13 cleaves laminin-5 (Ln-5) into small fragments to accelerate tumor metastasis. Degradation of Ln-5 and VE-cadherin by MMP-13 inhibited VM formation. In conclusion, MMP-13 has a dual effect in melanoma, as it promotes invasion and metastasis but disrupts VM formation. äDual effects of collagenase-3 on melanoma: metastasis promotion and di(epmc).pdf DeepDyve Pubget Overpricing