Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of
vasculogenic mimicry
#MMPMID25749207
Zhao X
; Sun B
; Li Y
; Liu Y
; Zhang D
; Wang X
; Gu Q
; Zhao J
; Dong X
; Liu Z
; Che N
Oncotarget
2015[Apr]; 6
(11
): 8890-9
PMID25749207
show ga
Vasculogenic mimicry (VM) is a functional microcirculation formed by tumor cells.
Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, promote VM
formation. Another specific MMP, collagenase-3 (MMP-13), has broad substrate
specificity and potentially affects tumor metastasis and invasion. Here we found
that MMP-13 was associated with metastasis and poor survival in 79 patients with
melanoma. MMP-13 expression was inversely correlated with VM. These results were
confirmed in human and mouse melanoma cell lines. We found that MMP-13 cleaves
laminin-5 (Ln-5) into small fragments to accelerate tumor metastasis. Degradation
of Ln-5 and VE-cadherin by MMP-13 inhibited VM formation. In conclusion, MMP-13
has a dual effect in melanoma, as it promotes invasion and metastasis but
disrupts VM formation.
free
free
free
