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http://scihub22266oqcxt.onion/ C4496167!4496167!25895124     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (11): 8567-78 Nephropedia Template TP {{tp|p=25895124|t=2015. Anti-?2-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy |pdf=|usr=}}{{25895124}} gab.com Text Anti- 2-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25895124 #FOAvip Our previous studies showed that anti-?2M monoclonal antibodies (mAbs) have strong and direct apoptotic effects on multiple myeloma (MM) cells, suggesting that anti-?2M mAbs might be developed as a novel therapeutic agent. In this study, we investigated the anti-MM effects of combination treatment with anti-?2M mAbs and bortezomib (BTZ). Our results showed that anti-?2M mAbs enhanced BTZ-induced apoptosis of MM cell lines and primary MM cells. Combination treatment could also induce apoptosis of BTZ-resistant MM cells, and the enhanced effect depended on the surface expression of ?2M on MM cells. BTZ up-regulated the expression of autophagy proteins, whereas combination with anti-?2M mAbs inhibited autophagy. Sequence analysis of the promoter region of beclin 1 identified 3 putative NF-?B-binding sites from ?615 to ?789 bp. BTZ treatment increased, whereas combination with anti-?2M mAbs reduced, NF-?B transcription activities in MM cells, and combination treatment inhibited NF-?B p65 binding to the beclin 1 promoter. Furthermore, anti-?2M mAbs and BTZ combination treatment had anti-MM activities in an established MM mouse model. Thus, our studies provide new insight and support for the clinical development of an anti-?2M mAb and BTZ combination treatment to overcome BTZ drug resistance and improve MM patient survival. Twit Text FOAVip Anti- 2-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25895124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25895124 #FOAvip English Wikipedia <ref>{{Cite pmid|25895124}}</ref> Anti-?2-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy #MMPMID25895124 Zhang M; He J; Liu Z; Lu Y; Zheng Y; Li H; Xu J; Liu H; Qian J; Orlowski RZ; Kwak LW; Yi Q; Yang J Oncotarget 2015[Apr]; 6 (11): 8567-78 PMID25895124show ga Our previous studies showed that anti-?2M monoclonal antibodies (mAbs) have strong and direct apoptotic effects on multiple myeloma (MM) cells, suggesting that anti-?2M mAbs might be developed as a novel therapeutic agent. In this study, we investigated the anti-MM effects of combination treatment with anti-?2M mAbs and bortezomib (BTZ). Our results showed that anti-?2M mAbs enhanced BTZ-induced apoptosis of MM cell lines and primary MM cells. Combination treatment could also induce apoptosis of BTZ-resistant MM cells, and the enhanced effect depended on the surface expression of ?2M on MM cells. BTZ up-regulated the expression of autophagy proteins, whereas combination with anti-?2M mAbs inhibited autophagy. Sequence analysis of the promoter region of beclin 1 identified 3 putative NF-?B-binding sites from ?615 to ?789 bp. BTZ treatment increased, whereas combination with anti-?2M mAbs reduced, NF-?B transcription activities in MM cells, and combination treatment inhibited NF-?B p65 binding to the beclin 1 promoter. Furthermore, anti-?2M mAbs and BTZ combination treatment had anti-MM activities in an established MM mouse model. Thus, our studies provide new insight and support for the clinical development of an anti-?2M mAb and BTZ combination treatment to overcome BTZ drug resistance and improve MM patient survival. äAnti-?2-microglobulin monoclonal antibodies overcome bortezomib resist(epmc).pdf DeepDyve Pubget Overpricing