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2009 ; 13
(7
): 1228-37
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Endocytosis via caveolae: alternative pathway with distinct cellular compartments
to avoid lysosomal degradation?
#MMPMID19382909
Kiss AL
; Botos E
J Cell Mol Med
2009[Jul]; 13
(7
): 1228-37
PMID19382909
show ga
Endocytosis--the uptake of extracellular ligands, soluble molecules, protein and
lipids from the extracellular surface--is a vital process, comprising multiple
mechanisms, including phagocytosis, macropinocytosis, clathrin-dependent and
clathrin-independent uptake such as caveolae-mediated and non-caveolar
raft-dependent endocytosis. The best-studied endocytotic pathway for
internalizing both bulk membrane and specific proteins is the clathrin-mediated
endocytosis. Although many papers were published about the caveolar endocytosis,
it is still not known whether it represents an alternative pathway with distinct
cellular compartments to avoid lysosomal degradation or ligands taken up by
caveolae can also be targeted to late endosomes/lysosomes. In this paper, we
summarize data available about caveolar endocytosis. We are especially focussing
on the intracellular route of caveolae and providing data supporting that
caveolar endocytosis can join to the classical endocytotic pathway.