Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/j.1582-4934.2008.00326.x http://scihub22266oqcxt.onion/10.1111/j.1582-4934.2008.00326.x C4496110!4496110 !18373731     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18373731 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2009 ; 13 (6 ): 1149-61 Nephropedia Template TP {{tp|p=18373731 |t=2009. Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence |pdf=|usr=}}{{18373731 }} gab.com Text Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=18373731 #FOAvip Hystidyl-proline [cyclo(His-Pro)] is an endogenous cyclic dipeptide produced by the cleavage of thyrotropin releasing hormone. Previous studies have shown that cyclo(His-Pro) protects against oxidative stress, although the underlying mechanism has remained elusive. Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells. Cyclo(His-Pro) attenuated reactive oxygen species production, and prevented glutathione depletion caused by glutamate, rotenone, paraquat and beta-amyloid treatment. Moreover, real-time PCR analyses revealed that cyclo(His-Pro) induced the expression of a number of ARE-related genes and protected cells against hydrogen peroxide-mediated apoptotic death. Furthermore, these effects were abolished by RNA interference-mediated Nrf2 knockdown. Finally, pharmacological inhibition of p-38 MAPK partially prevented both cyclo(His-Pro)-mediated Nrf2 activation and cellular protection. These results suggest that the signalling mechanism responsible for the cytoprotective actions of cyclo(His-Pro) would involve p-38 MAPK activation leading to Nrf2-mediated up-regulation of antioxidant cellular defence. Twit Text FOAVip Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=18373731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18373731 #FOAvip English Wikipedia <ref>{{Cite pmid|18373731 }}</ref> Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence #MMPMID18373731 Minelli A ; Conte C ; Grottelli S ; Bellezza I ; Cacciatore I ; Bolaņos JP J Cell Mol Med 2009[Jun]; 13 (6 ): 1149-61 PMID18373731 show ga Hystidyl-proline [cyclo(His-Pro)] is an endogenous cyclic dipeptide produced by the cleavage of thyrotropin releasing hormone. Previous studies have shown that cyclo(His-Pro) protects against oxidative stress, although the underlying mechanism has remained elusive. Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells. Cyclo(His-Pro) attenuated reactive oxygen species production, and prevented glutathione depletion caused by glutamate, rotenone, paraquat and beta-amyloid treatment. Moreover, real-time PCR analyses revealed that cyclo(His-Pro) induced the expression of a number of ARE-related genes and protected cells against hydrogen peroxide-mediated apoptotic death. Furthermore, these effects were abolished by RNA interference-mediated Nrf2 knockdown. Finally, pharmacological inhibition of p-38 MAPK partially prevented both cyclo(His-Pro)-mediated Nrf2 activation and cellular protection. These results suggest that the signalling mechanism responsible for the cytoprotective actions of cyclo(His-Pro) would involve p-38 MAPK activation leading to Nrf2-mediated up-regulation of antioxidant cellular defence. |Animals [MESH] |Antioxidants/*metabolism [MESH] |Apoptosis/drug effects [MESH] |Calcium/metabolism [MESH] |Cell Survival/drug effects [MESH] |Dose-Response Relationship, Drug [MESH] |Gene Expression/drug effects [MESH] |Glutamic Acid/pharmacology [MESH] |Glutathione/metabolism [MESH] |Hydrogen Peroxide/pharmacology [MESH] |NF-E2-Related Factor 2/genetics/*metabolism [MESH] |Oxidants/pharmacology [MESH] |Oxidative Stress/drug effects [MESH] |PC12 Cells [MESH] |Paraquat/pharmacology [MESH] |Peptides, Cyclic/*pharmacology [MESH] |Phosphorylation/drug effects [MESH] |Piperazines/*pharmacology [MESH] |RNA Interference [MESH] |Rats [MESH] |Reactive Oxygen Species/metabolism [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Rotenone/pharmacology [MESH] |Time Factors [MESH] |Up-Regulation/drug effects [MESH]Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-(epmc).pdf DeepDyve Pubget Overpricing