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10.1016/j.neurobiolaging.2013.03.032 http://scihub22266oqcxt.onion/10.1016/j.neurobiolaging.2013.03.032 C4496028!4496028 !23618870     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23618870 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neurobiol+Aging 2013 ; 34 (10 ): 2352-60 Nephropedia Template TP {{tp|p=23618870 |t=2013. Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer s disease |pdf=|usr=}}{{23618870 }} gab.com Text Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer s disease JO: Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=23618870 #FOAvip Amyloid beta (A?) is implicated in Alzheimer's disease (AD) as an integral component of both neural toxicity and plaque formation. Brains of the longest-lived rodents, naked mole-rats (NMRs) approximately 32 years of age, had levels of A? similar to those of the 3xTg-AD mouse model of AD. Interestingly, there was no evidence of extracellular plaques, nor was there an age-related increase in A? levels in the individuals examined (2-20+ years). The NMR A? peptide showed greater homology to the human sequence than to the mouse sequence, differing by only 1 amino acid from the former. This subtle difference led to interspecies differences in aggregation propensity but not neurotoxicity; NMR A? was less prone to aggregation than human A?. Nevertheless, both NMR and human A? were equally toxic to mouse hippocampal neurons, suggesting that A? neurotoxicity and aggregation properties were not coupled. Understanding how NMRs acquire and tolerate high levels of A? with no plaque formation could provide useful insights into AD, and may elucidate protective mechanisms that delay AD progression. Twit Text FOAVip Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer s disease ????Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=23618870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23618870 #FOAvip English Wikipedia <ref>{{Cite pmid|23618870 }}</ref> Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer s disease #MMPMID23618870 Edrey YH ; Medina DX ; Gaczynska M ; Osmulski PA ; Oddo S ; Caccamo A ; Buffenstein R Neurobiol Aging 2013[Oct]; 34 (10 ): 2352-60 PMID23618870 show ga Amyloid beta (A?) is implicated in Alzheimer's disease (AD) as an integral component of both neural toxicity and plaque formation. Brains of the longest-lived rodents, naked mole-rats (NMRs) approximately 32 years of age, had levels of A? similar to those of the 3xTg-AD mouse model of AD. Interestingly, there was no evidence of extracellular plaques, nor was there an age-related increase in A? levels in the individuals examined (2-20+ years). The NMR A? peptide showed greater homology to the human sequence than to the mouse sequence, differing by only 1 amino acid from the former. This subtle difference led to interspecies differences in aggregation propensity but not neurotoxicity; NMR A? was less prone to aggregation than human A?. Nevertheless, both NMR and human A? were equally toxic to mouse hippocampal neurons, suggesting that A? neurotoxicity and aggregation properties were not coupled. Understanding how NMRs acquire and tolerate high levels of A? with no plaque formation could provide useful insights into AD, and may elucidate protective mechanisms that delay AD progression. |*Aging/metabolism/pathology [MESH] |*Disease Models, Animal [MESH] |*Mole Rats [MESH] |Alzheimer Disease/metabolism/pathology/*prevention & control [MESH] |Amyloid beta-Peptides/*metabolism/*toxicity [MESH] |Animals [MESH] |Brain/*metabolism [MESH] |Cells, Cultured [MESH] |Disease Progression [MESH] |Female [MESH] |Hippocampus/cytology/drug effects [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH]Amyloid beta and the longest-lived rodent: the naked mole-rat as a mod(epmc).pdf DeepDyve Pubget Overpricing