Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncomms6759 http://scihub22266oqcxt.onion/10.1038/ncomms6759 C4495958!4495958!25536025     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2014 ; 5 (ä): 5759 Nephropedia Template TP {{tp|p=25536025|t=2014. Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior |pdf=|usr=}}{{25536025}} gab.com Text Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25536025 #FOAvip Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here, we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERB? and ?, regulate sleep architecture and emotional behavior in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behavior. These data are consistent with increased anxiety-like behavior of REV-ERB? null mice, in which REV-ERB agonists have no effect Also consistent with these effects being mediated by REV-ERB, the effect of the agonist on sleep and anxiety was suppressed by lithium treatment. These results indicate that pharmacological targeting of REVERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety. Twit Text FOAVip Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25536025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25536025 #FOAvip English Wikipedia <ref>{{Cite pmid|25536025}}</ref> Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior #MMPMID25536025 Banerjee S; Wang Y; Solt LA; Griffett K; Kazantzis M; Amador A; El-Gendy BM; Huitron-Resendiz S; Roberts AJ; Shin Y; Kamenecka TM; Burris TP Nat Commun 2014[]; 5 (ä): 5759 PMID25536025show ga Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here, we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERB? and ?, regulate sleep architecture and emotional behavior in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behavior. These data are consistent with increased anxiety-like behavior of REV-ERB? null mice, in which REV-ERB agonists have no effect Also consistent with these effects being mediated by REV-ERB, the effect of the agonist on sleep and anxiety was suppressed by lithium treatment. These results indicate that pharmacological targeting of REVERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety. äPharmacological Targeting of the Mammalian Clock Regulates Sleep Archi(epmc).pdf DeepDyve Pubget Overpricing