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10.1038/ncomms6759 http://scihub22266oqcxt.onion/10.1038/ncomms6759 C4495958!4495958 !25536025     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25536025 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2014 ; 5 (ä): 5759 Nephropedia Template TP {{tp|p=25536025 |t=2014. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour |pdf=|usr=}}{{25536025 }} gab.com Text Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25536025 #FOAvip Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERB? and ?, regulate sleep architecture and emotional behaviour in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behaviour. These data are consistent with increased anxiety-like behaviour of REV-ERB?-null mice, in which REV-ERB agonists have no effect. These results indicate that pharmacological targeting of REV-ERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety. Twit Text FOAVip Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25536025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25536025 #FOAvip English Wikipedia <ref>{{Cite pmid|25536025 }}</ref> Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour #MMPMID25536025 Banerjee S ; Wang Y ; Solt LA ; Griffett K ; Kazantzis M ; Amador A ; El-Gendy BM ; Huitron-Resendiz S ; Roberts AJ ; Shin Y ; Kamenecka TM ; Burris TP Nat Commun 2014[Dec]; 5 (ä): 5759 PMID25536025 show ga Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERB? and ?, regulate sleep architecture and emotional behaviour in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behaviour. These data are consistent with increased anxiety-like behaviour of REV-ERB?-null mice, in which REV-ERB agonists have no effect. These results indicate that pharmacological targeting of REV-ERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety. |ARNTL Transcription Factors/genetics/metabolism [MESH] |Animals [MESH] |Anxiety/*drug therapy/genetics/metabolism/physiopathology [MESH] |Behavior, Animal/*drug effects [MESH] |CLOCK Proteins/genetics/metabolism [MESH] |Circadian Clocks/*drug effects/genetics [MESH] |Circadian Rhythm/genetics [MESH] |Cryptochromes/genetics/metabolism [MESH] |Feedback, Physiological [MESH] |Gene Expression Regulation [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Nuclear Receptor Subfamily 1, Group D, Member 1/genetics/metabolism [MESH] |Period Circadian Proteins/genetics/metabolism [MESH] |Pyrrolidines/*pharmacology [MESH] |Receptors, Cytoplasmic and Nuclear/*agonists/genetics/metabolism [MESH] |Repressor Proteins/*agonists/genetics/metabolism [MESH] |Reward [MESH] |Signal Transduction [MESH] |Sleep, REM/*drug effects [MESH]Pharmacological targeting of the mammalian clock regulates sleep archi(epmc).pdf DeepDyve Pubget Overpricing