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10.1007/s00706-013-1067-7

http://scihub22266oqcxt.onion/10.1007/s00706-013-1067-7
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suck abstract from ncbi


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pmid26166876      Monatsh+Chem 2013 ; 144 (11): 1679-89
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  • Microwave-assisted preparation and antimicrobial activity of O-alkylamino benzofurancarboxylates #MMPMID26166876
  • Ostrowska K; Hejchman E; Wolska I; Kruszewska H; Maciejewska D
  • Monatsh Chem 2013[]; 144 (11): 1679-89 PMID26166876show ga
  • Abstract: A series of derivatives of 2 and 3-benzofurancarboxylates were synthesized under microwave-assisted conditions. Their in-vitro antimicrobial properties were assessed. Inhibition by the compounds of the growth of antibiotic-susceptible standards and clinically isolated strains of Gram-positive and Gram-negative bacteria, yeasts, and a human fungal pathogen was moderate to significant. Methyl 5-bromo-7-[2-(N,N-diethylamino)ethoxy]-6-methoxy-2-benzofurancarboxylate hydrochloride was identified as the most active compound (MIC 3?12 × 10?3 ?mol/cm3 against Gram-positive bacteria; MIC 9.4 × 10?2 ?mol/cm3 against Candida and Aspergillus brasiliensis). The molecular and crystal structures of 2-(N,N-diethylamino)ethyl 6-acetyl-5-hydroxy-2-methyl-3-benzofurancarboxylate were established by single-crystal X-ray diffraction. Graphical Abstract: .
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